Mass-spectrometric exploration of proteome structure and function

Numerous biological processes are concurrently and coordinately active in every living cell. Each of them encompasses synthetic, catalytic and regulatory functions that are, almost always, carried out by proteins organized further into higher-order structures and networks. For decades, the structure...

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Bibliographic Details
Published in:	Nature (London) Vol. 537; no. 7620; pp. 347 - 355
Main Authors:	Aebersold, Ruedi, Mann, Matthias
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15-09-2016 Nature Publishing Group
Subjects:	631/114 631/1647 631/45 631/553 Animals Genomes Humanities and Social Sciences Humans Mass Spectrometry Methods Molecular structure multidisciplinary Phenotype Protein Processing, Post-Translational Proteins Proteome - analysis Proteome - chemistry Proteome - metabolism Proteomics review-article Science Signal Transduction Spectrometry Studies
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Summary:	Numerous biological processes are concurrently and coordinately active in every living cell. Each of them encompasses synthetic, catalytic and regulatory functions that are, almost always, carried out by proteins organized further into higher-order structures and networks. For decades, the structures and functions of selected proteins have been studied using biochemical and biophysical methods. However, the properties and behaviour of the proteome as an integrated system have largely remained elusive. Powerful mass-spectrometry-based technologies now provide unprecedented insights into the composition, structure, function and control of the proteome, shedding light on complex biological processes and phenotypes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0028-0836 1476-4687
DOI:	10.1038/nature19949