Polarity and cell fate asymmetry in Caulobacter crescentus

Highlights ► Replicative asymmetry of Caulobacter daughter cells is dictated by CtrA. ► Two phosphorelays drive the phosphorylation and proteolytic stabilization of CtrA. ► CckA, the kinase for CtrA, must localize to a cell pole for maximal activation. ► CckA colocalizes with the phosphatase PleC to...

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Bibliographic Details
Published in:	Current opinion in microbiology Vol. 15; no. 6; pp. 744 - 750
Main Authors:	Tsokos, Christos G, Laub, Michael T
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2012
Subjects:	Animalia Bacterial Proteins - metabolism Caulobacter Caulobacter crescentus Caulobacter crescentus - physiology Cell Division Cell Polarity DNA-Binding Proteins - metabolism Gene Expression Regulation, Bacterial histidine kinase Metazoa microorganisms Pathology replication origin Signal Transduction transcription factors Transcription Factors - metabolism
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Summary:	Highlights ► Replicative asymmetry of Caulobacter daughter cells is dictated by CtrA. ► Two phosphorelays drive the phosphorylation and proteolytic stabilization of CtrA. ► CckA, the kinase for CtrA, must localize to a cell pole for maximal activation. ► CckA colocalizes with the phosphatase PleC to avoid downregulation by DivK∼P. ► Localization of DivJ and PleC to opposite poles helps establish replicative asymmetry.
Bibliography:	http://dx.doi.org/10.1016/j.mib.2012.10.011 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Feature-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2012.10.011