Cushing's Syndrome Masquerading as Treatment Resistant Depression

• Published in: Indian journal of psychological medicine Vol. 38; no. 3; pp. 246 - 248
• Main Authors: B. N., Anil Kumar, Grover, Sandeep
• Format: Journal Article
• Language: English
• Published: New Delhi, India SAGE Publications 01-05-2016; Wolters Kluwer - Medknow Publications; Sage Publications Ltd. (UK); Sage Publications, New Delhi India; Medknow Publications & Media Pvt Ltd; SAGE Publishing
• Subjects: Antiglucocorticoid drugs; Case Report; Cushing's syndrome; Depression (Mood disorder); Drug therapy; Ketoconazole; treatment-resistant depression; Tricyclic antidepressants; treatment-resistant depression; Antiglucocorticoid drugs; Cushing's syndrome
• ISSN: 0253-7176; 0975-1564
• DOI: 10.4103/0253-7176.183095

Treatment resistant depression (TRD) is a common clinical occurrence among patients treated for major depressive disorder. A significant proportion of patients remain significantly depressed in spite of aggressive pharmacological and psychotherapeutic approaches. Management of patient with treatment resistant depression requires thorough evaluation for physical causes. We report a case of recurrent depressive disorder, who presented with severe depressive episode without psychotic symptoms, not responding to multiple adequate trials of antidepressants, who on investigation was found to have Cushing's syndrome and responded well to Ketoconazole.