Neurobiological effects of gallic acid: current perspectives

• Published in: Chinese medicine Vol. 18; no. 1; p. 27
• Main Authors: Bhuia, Md Shimul, Rahaman, Md Mizanur, Islam, Tawhida, Bappi, Mehedi Hasan, Sikder, Md Iqbal, Hossain, Kazi Nadim, Akter, Fatama, Al Shamsh Prottay, Abdullah, Rokonuzzman, Md, Gürer, Eda Sönmez, Calina, Daniela, Islam, Muhammad Torequl, Sharifi-Rad, Javad
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15-03-2023; BioMed Central; BMC
• Subjects: Alzheimer's disease; Analysis; Bioavailability; Brain health; Drug dosages; Drug therapy; Fatalities; Fruits; Gallic acid; Gallic acid; neuroprotective activity; pharmacological effects; Hydrocarbons; Inflammation; Ischemia; Laboratory animals; Medical research; Medicinal plants; Medicine, Botanic; Medicine, Experimental; Medicine, Herbal; Metabolism; Metabolites; Molecular mechanisms; Movement disorders; Nanomaterials; Nanotechnology; Nervous system diseases; Neuralgia; Neurodegenerative diseases; Neurological diseases; Neuroprotection; Oils & fats; Parkinson's disease; Peptides; Pharmacokinetics; Pharmacology; Phenols; Polyphenols; Psychosis; Review; Urine; Brain health; Gallic acid; neuroprotective activity; pharmacological effects; Molecular mechanisms
• ISSN: 1749-8546; 1749-8546
• DOI: 10.1186/s13020-023-00735-7

Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer's disease, Parkinson's disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.