A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction

• Published in: Allergy, asthma, and clinical immunology Vol. 17; no. 1; p. 36
• Main Authors: Abe, Sumiko, Ito, Jun, Harada, Sonoko, Sasano, Hitoshi, Ueda, Shoko, Sandhu, Yuuki, Takeshige, Tomohito, Katsura, Yoko, Harada, Norihiro, Takahashi, Kazuhisa
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31-03-2021; BioMed Central; BMC
• Subjects: Allergens; Allergy; Analysis; Anaphylaxis; Angioedema; Angioneurotic edema; Antibodies; Antigens; Case Report; Edema; Food allergies; Food allergy; Hand eczema; Histamine; Immunoglobulin E; Japanese radish; Laboratories; Membranes; Oral allergy; Patients; Pollen; Proteins; Pruritus; Radishes; Skin; Testing; Urticaria; Vegetables; Japan; United States > US; Oral allergy; Japanese radish; Hand eczema
• ISSN: 1710-1484; 1710-1492; 1710-1492
• DOI: 10.1186/s13223-021-00538-1

Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.
A 48-year-old woman developed urticarial lesions on her hands after grating Japanese radish and also developed lip edema and oral itching when she ate a salad composed of raw Japanese radishes. Skin prick testing was positive to extract of grated Japanese radish. Moreover, immunoblotting analysis showed IgE reactivity in the patient's serum to a single band at the 18 kDa in grated Japanese radish, suggesting that the heat-labile 18 kDa protein of raw Japanese radish may be a radish-specific antigen.
To the best of our knowledge, this is the first case report of a patient with hand urticaria, lip angioedema, and oropharyngeal pruritus to raw Japanese radish through IgE-mediated immediate allergic reaction.