Hypertension is statistically associated with higher body mass index but not with vitamin D level in a Thai population

• Published in: European journal of clinical nutrition Vol. 66; no. 3; pp. 405 - 407
• Main Authors: Sumriddetchkajorn, K, Chailurkit, L, Thakkinstian, A, Sritara, P
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-03-2012; Nature Publishing Group
• Subjects: Adult; Alfacalcidol; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Body Mass Index; Body size; Body weight; Calcifediol; Calciferol; Cardiology. Vascular system; Cholesterol; Cholesterol, HDL - blood; Clinical Nutrition; Development and progression; Epidemiology; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Health aspects; High density lipoprotein; Humans; Hypertension; Hypertension - blood; Hypertension - etiology; Internal Medicine; Male; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Obesity - blood; Obesity - complications; Odds Ratio; Overweight; Physiological aspects; Public Health; Regression Analysis; short-communication; Statistical analysis; Thailand - epidemiology; Triglycerides; Triglycerides - blood; Tropical environment; Tropical environments; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vitamin D; Vitamin D - blood; Vitamin D Deficiency - blood; Vitamin D Deficiency - epidemiology; Vitamin deficiency; Asia; Thailand; 25-hydroxyvitamin D; Asia; hypertension; tropics; vitamin D deficiency; Human; Hypertension; Steroid hormone; Nutrition disorder; Cardiovascular disease; Metabolic diseases; Retinol; Body mass index; Association; Vitamin D; Cholecalciferol(25-hydroxy); Nutritional status
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2011.156

Vitamin D deficiency has been linked to hypertension. Although vitamin D deficiency is common in tropical regions, no data on its association with hypertension were available. We randomly selected 137 cases and controls whose plasma in 1985 was available for the assessment of vitamin D status and calculated the odds ratio of having hypertension in 1997. In all, 36% of the participants were vitamin D deficient. The odds ratio of having hypertension was marginally significant for vitamin D deficiency (0.59,
P
=0.05) and statistically significant for body mass index (BMI)-defined overweight (1.8,
P
=0.02). The inverse relationship between vitamin D deficiency and hypertension became statistically significant after further adjustment for BMI, high-density lipoprotein cholesterol and triglyceride (0.55,
P
=0.03). Stepwise regression identified BMI-defined overweight and vitamin D deficiency as the variables of significance in relation to hypertension. Our data suggest that vitamin D deficiency, although not a rarity in Thailand, was not associated with an increased risk of developing hypertension in Thai people.