Coffee consumption and the risk of prostate cancer: the Ohsaki Cohort Study

• Published in: British journal of cancer Vol. 108; no. 11; pp. 2381 - 2389
• Main Authors: Li, Q, Kakizaki, M, Sugawara, Y, Tomata, Y, Watanabe, T, Nishino, Y, Tsuji, I
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11-06-2013; Nature Publishing Group
• Subjects: Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Coffee; Cohort analysis; Cohort Studies; Drug Resistance; Epidemiology; Health care; Humans; Incidence; Japan - epidemiology; Lifestyles; Male; Medical research; Medical sciences; Medicine; Middle Aged; Molecular Medicine; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Nephrology. Urinary tract diseases; Oncology; Population; Prospective Studies; Prostate cancer; Prostatic Neoplasms - epidemiology; Public health; Questionnaires; Reproducibility; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Japan; neoplasm; prostate; incidence; prospective study; coffee; Consumption; Urinary system disease; Prostate disease; Risk; Malignant tumor; Coffee; Epidemiology; Incidence; Prospective; Cancerology; Cohort study; Risk factor; Urogenital system; Male genital diseases; Prostate cancer; Prostate; Cancer
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.2013.238

Background:
Epidemiological evidence regarding the effect of coffee on the incidence of prostate cancer is inconsistent. We aimed to investigate coffee consumption and the risk of prostate cancer risk in a general Japanese population.
Methods:
We conducted a prospective cohort study in Ohsaki city, Japan, where 18 853 men aged 40–79 years participated in a baseline survey. Coffee consumption was assessed via a validated self-administered questionnaire. During 11 years of follow-up (from January 1 1995 to December 31, 2005), 318 incident cases of prostate cancer were detected. The Cox proportional hazards regression model was used to calculate the hazard ratios (HRs) and 95% confidence interval (CIs).
Results:
There was a significant inverse association between coffee consumption and the incidence risk of prostate cancer. Compared with those who did not drink coffee, the multivariate adjusted HRs were 0.81 (95% CI: 0.61–1.07), 0.73 (95% CI: 0.53–1.00), and 0.63 (095% CI: 0.39–1.00) for those who drank coffee occasionally, 1–2 cups per day, and ⩾3 cups per day, respectively, with a
P
for trend of 0.02.
Conclusion:
This prospective finding from a Japanese population adds evidence that coffee intake is inversely associated with the incidence of prostate cancer.