A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking

• Published in: Leukemia Vol. 29; no. 4; pp. 776 - 782
• Main Author: Ratajczak, M Z
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-04-2015; Nature Publishing Group
• Subjects: 13; 13/100; 631/136/532/1542; 631/532/1542; 631/61/51/1844/2319; 64; 692/700/565/545/576/1955; Adult; Bone Marrow - immunology; Bone Marrow - metabolism; Bone Marrow Cells - classification; Bone Marrow Cells - cytology; Bone Marrow Cells - immunology; Bone Marrow Cells - metabolism; Cancer Research; Care and treatment; Cell Lineage - genetics; Cell Lineage - immunology; Cell Movement; Chemokine CXCL12 - genetics; Chemokine CXCL12 - immunology; Complement System Proteins - genetics; Critical Care Medicine; Gene Expression; Genetic aspects; Germ Cells - cytology; Germ Cells - immunology; Germ Cells - metabolism; Hematology; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - immunology; Hematopoietic Stem Cells - metabolism; Humans; Intensive; Internal Medicine; Leukemia; Medicine; Medicine & Public Health; Oncology; Physiological aspects; Review; United States
• ISSN: 0887-6924; 1476-5551
• DOI: 10.1038/leu.2014.346

This review presents a novel view and working hypothesis about the hierarchy within the adult bone marrow stem cell compartment and the still-intriguing question of whether adult bone marrow contains primitive stem cells from early embryonic development, such as cells derived from the epiblast, migrating primordial germ cells or yolk sac-derived hemangioblasts. It also presents a novel view of the mechanisms that govern stem cell mobilization and homing, with special emphasis on the role of the complement cascade as a trigger for egress of hematopoietic stem cells from bone marrow into blood as well as the emerging role of novel homing factors and priming mechanisms that support stromal-derived factor 1-mediated homing of hematopoietic stem/progenitor cells after transplantation.