1490-P: Levels of Specific Antibodies (Ab) for Sars Cov2 after Vaccination and Its Relationship with Clinical and Metabolic Variables in People with Type 2 Diabetes vs. Controls without Diabetes

• Published in: Diabetes (New York, N.Y.) Vol. 72; no. Supplement_1; p. 1
• Main Authors: POMARES, MARIA L., CUZZIOL, GABRIELA, LOPEZ, CLAUDIO E., KREMER SENDROS, SANDRA, POMARES, DAMIAN, OJEDA, MARIANA, WOLFFENBUTTEL CARLOTO, VICTOR, TEJADA, RINA M., OJEDA, GONZALO A., FIGUERERO, ANTONELA, GOMEZ MARTIN, CAROLINA, GORBAN DE LAPERTOSA, SILVIA
• Format: Journal Article
• Language: English
• Published: New York American Diabetes Association 20-06-2023
• Subjects: Age; Bone diseases; Comorbidity; COVID-19; Diabetes; Diabetes mellitus (non-insulin dependent); Immune response (humoral); Immunoglobulin G; Multivariate analysis; Rheumatic diseases; Statistical analysis; Vaccines
• ISSN: 0012-1797; 1939-327X
• DOI: 10.2337/db23-1490-P

Introduction: The COVID-19 pandemic has affected people all over the world, and even more seriously people with chronic pathologies.
Objectives: Primary: To evaluate the humoral immune response (IgG Ab specific for SARS CoV-2) in adults with DM2 versus controls. Secondary: To evaluate the relationship between Ab IgG levels and the presence of other clinical variables and comorbidities.
Materials and Methods: The study was carried out in January 2022 in Argentina. Adults with DM2 and controls who had received first and second doses of any SARS Cov-2 vaccines were included. Titers of Ac IgG were performed through the assay of IgG anti RBD (receptor binding domain in the host cell). Multiple Logistic Regression and Multiple Linear Regression were used. p value <0.05 was considered statistically significant.
Results: N 144 participants (91 with DM2 and 53 controls). Median from the second dose of a vaccine to the measurement of Ab: 141 days in controls and 144 in diabetics (p=0.451). The logarithm of the Ab titers were significantly lower in patients with DM2 vs. controls (p<0.01). Univariate analysis: Ab levels were positively and significantly related to BMI (p<0.01). They were also significantly associated with age (p<0.001) and with the presence of rheumatic diseases (p= 0.02). Multivariate analysis: Ab levels were only significantly and negatively associated with age (p<0.01) and the presence of rheumatologic bone disease (p=0.02). No differences were found between the type of vaccines used.
Conclusion: Although the Ab titers registered in DM2 were significantly lower vs. controls, the adjustment for various covariates have not allowed to sustain the significance of this association in multivariate analysis. The role of age, BMI, the presence of rheumatic diseases and other factors should be explored in other studies in order to evaluate their potential role as confounders.