Repetitive acute intermittent hypoxia increases growth/neurotrophic factor expression in non-respiratory motor neurons

• Published in: Neuroscience Vol. 322; pp. 479 - 488
• Main Authors: Satriotomo, I, Nichols, N.L, Dale, E.A, Emery, A.T, Dahlberg, J.M, Mitchell, G.S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 13-05-2016
• Subjects: Animals; BDNF; Brain-Derived Neurotrophic Factor - metabolism; Cervical Vertebrae; HIF-1; Hypoxia - metabolism; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Immunohistochemistry; intermittent hypoxia; Lumbar Vertebrae; Male; Motor Cortex - metabolism; Motor Cortex - pathology; motor neuron; Motor Neurons - metabolism; Motor Neurons - pathology; Neurology; Phosphorylation; Random Allocation; Rats, Sprague-Dawley; Receptor, trkB - metabolism; Spinal Cord - metabolism; Spinal Cord - pathology; TrkB; Vascular Endothelial Growth Factor A - metabolism; VEGF; tropomyosin receptor kinase B; pMF; HIF-1α; repetitive acute intermittent hypoxia; HIF-1; dAIH; pTrkB; rAIH; brain-derived neurotrophic factor; IH; AIH; NTRK2; phrenic long-term facilitation; Neurotrophic Tyrosine Kinase Receptor 2; BDNF; daily AIH; VEGF; phrenic motor facilitation; intermittent hypoxia; TrkB; hypoxia-inducible factor-1α; phosphorylated TrkB; vascular endothelial growth factor; motor neuron; acute intermittent hypoxia; pLTF
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2016.02.060

Highlights • 3 × wAIH is a modest protocol of chronic intermittent hypoxia (CIH). • Repetitive AIH (rAIH) enhances protein expression (BDNF and VEGF) and its high-affinity receptors (TrkB and VEGFR-2) in non-respiratory motor neurons. • rAIH induces transcription factor HIF-1α, a key regulator responsible for induction hypoxia-regulated genes, in spinal motor neurons. • rAIH may restore lost motor function, such as spinal injury and motor neuron disease.