Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease

• Published in: Nature biotechnology Vol. 39; no. 9; pp. 1078 - 1085
• Main Authors: Gilron, Ro’ee, Little, Simon, Perrone, Randy, Wilt, Robert, de Hemptinne, Coralie, Yaroshinsky, Maria S., Racine, Caroline A., Wang, Sarah S., Ostrem, Jill L., Larson, Paul S., Wang, Doris D., Galifianakis, Nick B., Bledsoe, Ian O., San Luciano, Marta, Dawes, Heather E., Worrell, Gregory A., Kremen, Vaclav, Borton, David A., Denison, Timothy, Starr, Philip A.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-09-2021; Nature Publishing Group
• Subjects: 631/378/1689/1718; 631/378/1697; Adaptation, Physiological; Adult; Agriculture; Analysis; Basal ganglia; Bioinformatics; Biomarkers; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Brain; Brain stimulation; Care and treatment; Circuits; Computer applications; Cortex (motor); Deep Brain Stimulation; Disorders; Female; Ganglia; Humans; Implantation; Implants; Implants, Artificial; Life Sciences; Male; Methods; Middle Aged; Motor Cortex - physiopathology; Movement; Movement disorders; Neural coding; Neural prostheses; Neural recording; Neurodegenerative diseases; Neuromodulation; Neurophysiological Monitoring - methods; Parkinson Disease - physiopathology; Parkinson Disease - therapy; Parkinson's disease; Prosthesis; Sensors; Stimulation; Wearable Electronic Devices; Wireless Technology; United States
• ISSN: 1087-0156; 1546-1696
• DOI: 10.1038/s41587-021-00897-5

Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson’s disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation.
An implanted device in the brain enables wireless neural monitoring and stimulation for up to 15 months following implantation.