The intriguing phenomenon of cross-kingdom infections of plant and insect viruses to fungi: Can other animal viruses also cross-infect fungi?

• Published in: PLoS pathogens Vol. 19; no. 10; p. e1011726
• Main Authors: Andika, Ida Bagus, Cao, Xinran, Kondo, Hideki, Sun, Liying
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 26-10-2023; Public Library of Science (PLoS)
• Subjects: Animals; Antifungal agents; Arthropods; Biology and Life Sciences; Control; Cross-infection; Epidemiology; Fungal diseases of plants; Fungi; Fungi, Pathogenic; Genomes; Glycoproteins; Health aspects; Host plants; Identification and classification; Infections; Insect viruses; Insects; Medicine and Health Sciences; Natural environment; Nutrients; Opinion; Parasites; Plant viruses; Prevention; Proteins; Risk factors; RNA polymerase; Taxonomy; Viral diseases; Viroids; Viruses; Yeast; China; Japan
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1011726

Fungi are highly widespread and commonly colonize multicellular organisms that live in natural environments. Notably, studies on viruses infecting plant-associated fungi have revealed the interesting phenomenon of the cross-kingdom transmission of viruses and viroids from plants to fungi. This implies that fungi, in addition to absorbing water, nutrients, and other molecules from the host, can acquire intracellular parasites that reside in the host. These findings further suggest that fungi can serve as suitable alternative hosts for certain plant viruses and viroids. Given the frequent coinfection of fungi and viruses in humans/animals, the question of whether fungi can also acquire animal viruses and serve as their hosts is very intriguing. In fact, the transmission of viruses from insects to fungi has been observed. Furthermore, the common release of animal viruses into the extracellular space (viral shedding) could potentially facilitate their acquisition by fungi. Investigations of the cross-infection of animal viruses in fungi may provide new insights into the epidemiology of viral diseases in humans and animals.