Ovulated oocytes in adult mice derive from non-circulating germ cells

Decades of research in reproductive biology have led to the generally accepted belief that in female mammals, all surviving germ cells enter meiosis at the end of fetal development and as a result, the postnatal ovary harbours a limited supply of oocytes that cannot be replenished or regenerated if...

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Bibliographic Details
Published in:	Nature Vol. 441; no. 7097; pp. 1109 - 1114
Main Authors:	Jurga, Sara, Min, Irene M, Gosden, Roger, Wagers, Amy J, Eggan, Kevin
Format:	Journal Article
Language:	English
Published:	London Nature Publishing 29-06-2006 Nature Publishing Group
Subjects:	Animal reproduction Animals Biological and medical sciences Blood Bone marrow Bone Marrow Cells - cytology Bone Marrow Transplantation Cell Differentiation Cell Lineage Cellular biology Female Females Fertility Fundamental and applied biological sciences. Psychology Leukocytes - cytology Mammalian female genital system Mammals Mice Mice, Inbred C57BL Morphology. Physiology Oocytes - cytology Oocytes - drug effects Oocytes - physiology Ovary - cytology Ovary - drug effects Ovary - pathology Ovary - physiology Ovulation - physiology Ovum - cytology Physiology Reproducibility of Results Rodents Vertebrates: reproduction Vertebrata Mammalia Mouse Rodentia Adult animal Homeostasis Bone marrow Female Germinal cell Ovulation Oocyte
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