Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

• Published in: Scientific reports Vol. 11; no. 1; p. 2366
• Main Authors: Lee, Juncheol, Kim, Bongyoung, Kim, Wonhee, Ahn, Chiwon, Choi, Hyun Young, Kim, Jae Guk, Kim, Jihoon, Shin, Hyungoo, Kang, Jun Goo, Moon, Shinje
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27-01-2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163; 692/163/2743; 692/308/174; Adipose tissue; Adult; Biomarkers - blood; Blood Glucose - metabolism; Body mass index; Endocrine System Diseases - epidemiology; Female; Homeostasis; Humanities and Social Sciences; Humans; Insulin; Insulin Resistance; Laboratory tests; Lipids; Lipids - blood; Male; Metabolic Diseases - epidemiology; Middle Aged; multidisciplinary; Population studies; Population Surveillance; Risk assessment; ROC Curve; Science; Science (multidisciplinary); Triglycerides; United States - epidemiology; Young Adult; United States; United States > US
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-82053-2

This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.