Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

• Published in: BMC chemistry Vol. 12; no. 1; pp. 112 - 17
• Main Authors: Dhiman, Priyanka, Malik, Neelam, Khatkar, Anurag
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 09-11-2018; Springer Nature B.V; BMC
• Subjects: Antioxidants; Caffeic acid derivatives; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Derivatives; DPPH and H2O2 activity; Hydrogen peroxide; In silico design; Inhibitors; Molecular docking; Monoamine oxidase; Organic and Medicinal Chemistry; Oxidase; Research Article; Scavenging; Selectivity; Side effects; Monoamine oxidase; In silico design; DPPH and H; activity; Caffeic acid derivatives; O; DPPH and H2O2 activity
• ISSN: 1752-153X; 1752-153X; 2661-801X
• DOI: 10.1186/s13065-018-0481-7

Background
Monoamine oxidase has been implicated in numerous neurological disorders. Although synthetic monoamine oxidase inhibitors (MAOI) have emerged with many side effects, the aspiration of natural based MAOI has greatly increased. As they exhibit fewer side effects and food interaction along with improved neuropharmacological profile.
Results
The in silico design of the caffeic acid derivatives led potent MAO inhibitors with remarkable antioxidant activity. The mechanistic insight of the compounds within the hMAO active site was achieved by molecular docking which led us to be more confident of the possible inhibition of MAO.
Conclusions
The synthesized eugenol based ester of caffeic acid compound
7
exhibited MAO-A inhibition with IC
50
values of 07.03 ± 0.022 µM with good selectivity (SI = 0.291) towards MAO-A. Conversely, two anilides compounds
2
and
1
, bearing chloro and nitro group at 2, 4 positions showed MAO-A inhibition with IC
50
values of 08.51 ± 0.017 µM and 08.87 ± 0.005 µM, respectively. Only one compound
5
was found as a significant MAO-B inhibitor with the IC
50
value of 10.80 ± 0.024 µM. Moreover, compounds
1
,
2
,
4
and
9
have profoundly appeared as potent antioxidants as evaluated in duel assay by scavenging DPPH and H
2
O
2
.