Cut-off value of total adiponectin for managing risk of developing metabolic syndrome in male Japanese workers

• Published in: PloS one Vol. 10; no. 2; p. e0118373
• Main Authors: Hata, Akiko, Yonemoto, Koji, Shikama, Yosuke, Aki, Nanako, Kosugi, Chisato, Tamura, Ayako, Ichihara, Takako, Minagawa, Takako, Kuwamura, Yumi, Miyoshi, Masashi, Nakao, Takayuki, Funaki, Makoto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23-02-2015; Public Library of Science (PLoS)
• Subjects: Adiponectin; Adiponectin - blood; Adult; Alcohol use; Asian Continental Ancestry Group; Biomarkers - blood; Body Mass Index; Cardiovascular disease; Coronary vessels; Diabetes; Epidemiology; Family medical history; Fasting; Hospitals; Humans; Japan; Kinases; Laboratories; Male; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - ethnology; Metabolic Syndrome - prevention & control; Multivariate Analysis; Nursing; Occupational Diseases - blood; Occupational Diseases - ethnology; Occupational Diseases - prevention & control; Prospective Studies; Reference Values; Risk Factors; Risk management; Science; Studies; Substance abuse treatment; Surveys and Questionnaires; Triglycerides; Workers; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0118373

To determine the optimal cut-off value of serum total adiponectin for managing the risk of developing metabolic syndrome (MetS) in male Japanese workers.
A total of 365 subjects without MetS aged 20-60 years were followed up prospectively for a mean of 3.1 years. The accelerated failure-time model was used to estimate time ratio (TR) and cut-off value for developing MetS.
During follow-up, 45 subjects developed MetS. Age-adjusted TR significantly declined with decreasing total adiponectin level (≤ 4.9, 5.0-6.6, 6.7-8.8 and ≥ 8.9 μg/ml, P for trend = 0.003). In multivariate analyses, TR of MetS was 0.12 (95% CI 0.02-0.78; P = 0.03) in subjects with total adiponectin level of 5.0-6.6 μg/ml, and 0.15 (95% CI 0.02-0.97; P = 0.047) in subjects with total adiponectin level ≤ 4.9 μg/ml compared with those with total adiponectin level ≥ 8.9 μg/ml. The accelerated failure-time model showed that the optimal cut-off value of total adiponectin for managing the risk of developing MetS was 6.2 μg/ml. In the multivariate-adjusted model, the mean time to the development of MetS was 78% shorter for total adiponectin level ≤ 6.2 μg/ml compared with > 6.2 μg/ml (TR 0.22, 95% CI: 0.08-0.64, P = 0.005).
Our findings suggest that the cut-off value for managing the risk of developing MetS is 6.2 μg/ml in male Japanese workers. Subjects with total adiponectin level ≤ 6.2 μg/ml developed MetS more rapidly than did those with total adiponectin level > 6.2 μg/ml.