HLA-C Alleles and Cytomegalovirus Retinitis in Brazilian Patients with AIDS

• Published in: Journal of ophthalmology Vol. 2018; no. 2018; pp. 1 - 5
• Main Authors: Donadi, Eduardo Antônio, Castelli, Erick C., Paula, Jayter Silva de, Deghaide, Neifi Hassan Salum, Fernandes, Ana Paula Morais, Veronese Rodrigues, Maria de Lourdes, Biberg-Salum, Tânia Gisela, Mendes-Junior, Celso T.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acquired immune deficiency syndrome; AIDS; AIDS (Disease); Allelomorphism; Cytomegalovirus; Cytomegalovirus infections; Deoxyribonucleic acid; DNA; Drug therapy; Histocompatibility antigens; HIV; HIV patients; HLA histocompatibility antigens; Human immunodeficiency virus; Infections; Medical research; Medicine, Experimental; Patients; Polymorphism; Retinal diseases; Brazil
• ISSN: 2090-004X; 2090-0058
• DOI: 10.1155/2018/3830104

Purpose. Since cytomegalovirus retinitis (CR) is an important cause of visual impairment among AIDS patients and HLA-C alleles have been associated with AIDS disease outcome, we typed HLA-C locus in patients with AIDS exhibiting or not CR. Methods. Three groups of individuals were studied: (i) 49 patients with AIDS and CR (Group I), (ii) 161 patients with AIDS without CR (Group II), and (iii) 202 healthy HIV-negative individuals (Group III). HLA-C typing was performed using commercial kits. Results. The HLA-C∗07 allele group was underrepresented in AIDS patients with CR (P=0.005) when compared to controls or when compared to AIDS patients without CR (P=0.006). The HLA-C∗05 allele group was overrepresented in Group II in comparison to Group III (P=0.017). The frequency of the HLA-C∗16 allele group was increased in Group III in comparison to Group II (P=0.004). Conclusion. The HLA-C∗07 allele group conferred protection against the development of CR in Brazilian AIDS patients, whereas the HLA-C∗05 and HLA-C∗16 allele groups were associated with AIDS susceptibility or protection, respectively.