Involvement of Fluctuating High Blood Pressure in the Enlargement of Spontaneous Intracerebral Hematoma

• Published in: Neurologia medico-chirurgica Vol. 41; no. 6; pp. 300 - 305
• Main Authors: MARUISHI, Masaharu, SHIMA, Takeshi, OKADA, Yoshikazu, NISHIDA, Masahiro, YAMANE, Kanji
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 2001; THE JAPAN NEUROSURGICAL SOCIETY
• Subjects: Aged; blood pressure; Cerebral Hemorrhage - complications; Cerebral Hemorrhage - diagnostic imaging; Cerebral Hemorrhage - physiopathology; enlargement; Female; Humans; Hypertension - complications; Male; Middle Aged; Risk Factors; spontaneous intracerebral hemorrhage; Tomography, X-Ray Computed
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/nmc.41.300

The correlations between changes in blood pressure after admission and hematoma expansion were investigated in 118 patients with spontaneous intracerebral hematoma admitted within 24 hours of onset who underwent serial computed tomography. Multiple logistic regression was performed to assess correlations between hematoma enlargement and clinical characteristics on admission. Hematoma enlargement was predominantly correlated with time of onset (p = 0.01567), and not well correlated with blood pressure at admission (p = 0.07908). Serial changes in blood pressure were investigated in 57 patients admitted within 6 hours of ictus whose blood pressures were monitored every hour from admission. Wilcoxon signed-rank analysis was used to determine the relationships between hematoma enlargement and blood pressure. Patients with hematoma enlargement was significantly correlated with increased blood pressure (p = 0.0004). Increases in blood pressure after admission may be a factor in hematoma enlargement.