Pneumococcal vaccination programs and the burden of invasive pneumococcal disease in Ontario, Canada, 1995–2011

• Published in: Vaccine Vol. 31; no. 49; pp. 5863 - 5871
• Main Authors: Rudnick, Wallis, Liu, Zhong, Shigayeva, Altynay, Low, Donald E, Green, Karen, Plevneshi, Agron, Devlin, Roslyn, Downey, James, Katz, Kevin, Kitai, Ian, Krajden, Sigmund, Ostrowska, Krystyna, Richardson, David, Richardson, Susan, Sarabia, Alicia, Silverman, Michael, Simor, Andrew E, Tyrrell, Gregory, McGeer, Allison
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 02-12-2013; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Allergy and Immunology; Applied microbiology; bacteremia; Bacterial diseases; Bacteriology; Biological and medical sciences; Case fatality; Child; Child, Preschool; children; Children & youth; Cost of Illness; elderly; Fatalities; Female; Fundamental and applied biological sciences. Psychology; Heptavalent Pneumococcal Conjugate Vaccine; Herd immunity; herds; Human bacterial diseases; Humans; immunity; Immunization Programs; Incidence; Infant; Infant, Newborn; Infectious diseases; Invasive pneumococcal disease; Laboratories; Male; Medical research; Medical sciences; Microbiology; Middle Aged; Miscellaneous; monitoring; morbidity; Mortality; multivariate analysis; nursing homes; Older people; Ontario - epidemiology; Pneumococcal Infections - epidemiology; Pneumococcal Infections - mortality; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - administration & dosage; Population Surveillance; Public health; serotypes; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcus pneumoniae; vaccination; Vaccination programs; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Conjugate - administration & dosage; Young Adult; Ontario; Canada; North America; America; Ontario Canada; Case fatality; Invasive pneumococcal disease; Vaccination programs; Infection; Streptococcaceae; Streptococcal infection; Vaccination; Bacteriosis; Bacteria; Micrococcales; Pneumococcal infection; Streptococcus pneumoniae
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.09.049

Highlights • Routine pediatric PCV7 vaccination did not reduce in the incidence of IPD in adults in Toronto. • Use of PCV7 at 1 dose per child in the birth cohort resulted in significant reductions in PCV7 serotype IPD. • The case fatality rate of IPD decreased by 2% per year in Toronto between 1995 and 2011. • Post PCV13 program implementation, a substantial burden of IPD in adults will remain.