Invasive group B streptococcal infections in adults, France (2007–2010)

• Published in: Clinical microbiology and infection Vol. 17; no. 10; pp. 1587 - 1589
• Main Authors: Tazi, A., Morand, P.C., Réglier-Poupet, H., Dmytruk, N., Billoët, A., Antona, D., Trieu-Cuot, P., Poyart, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01-10-2011; Blackwell Publishing Ltd; Wiley-Blackwell; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antibacterial agents; Antibiotic resistance; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteremia - epidemiology; Bacteremia - microbiology; Bacterial Capsules - analysis; Bacterial diseases; Biological and medical sciences; Bone and Bones - microbiology; capsular serotype; Drug Resistance, Bacterial; Erythromycin - pharmacology; Female; France - epidemiology; GBS; Genes, Bacterial; Human bacterial diseases; Humans; Infectious diseases; invasive infections; Joints - microbiology; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Phenotype; Staphylococcal infections, streptococcal infections, pneumococcal infections; Streptococcal Infections - epidemiology; Streptococcal Infections - microbiology; Streptococcus; Streptococcus agalactiae; Streptococcus agalactiae - drug effects; Streptococcus agalactiae - genetics; Streptococcus agalactiae - pathogenicity; Young Adult; France; Europe; GBS; capsular serotype; Streptococcus agalactiae; Antibiotic resistance; invasive infections; Human; Typing; Infection; Resistance; Streptococcaceae; Antibiotic; Microbiological investigation; Streptococcal infection; Streptococcus B; Bacteriosis; Bacteria; Micrococcales; Adult; Serotype; Antibacterial agent
• ISSN: 1198-743X; 1469-0691
• DOI: 10.1111/j.1469-0691.2011.03628.x

Group B streptococcus (GBS) has emerged as an important cause of invasive infection in adults. Here, we report the clinical and microbiological characteristics of 401 non-redundant GBS strains causing adult invasive infections collected during a 4-year period (2007–2010). Bacteraemia without focus (43.4%) and bone and joint infections (18.7%) were the main clinical manifestations. The distribution of capsular polysaccharide (CPS) type showed that types Ia, III, and V accounted for 71.8% of all strains. Resistance to erythromycin increased from 20.2% in 2007 to 35.3% in 2010, and was mainly associated with CPS type V harbouring the erm(B) resistant determinant.