Association between displacement and thickness of macula after vitrectomy in eyes with epiretinal membrane

• Published in: Scientific reports Vol. 10; no. 1; p. 13227
• Main Authors: Momota, Ayana, Iwase, Takeshi, Akahori, Tomohiko, Goto, Kensuke, Yamamoto, Kentaro, Ra, Eimei, Terasaki, Hiroko
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06-08-2020; Nature Publishing Group
• Subjects: 692/308/409; 692/700/1421; Aged; Angiography; Cataracts; Cross-Sectional Studies; Epiretinal Membrane - pathology; Epiretinal Membrane - surgery; Eye; Female; Horizontal cells; Hospitals; Humanities and Social Sciences; Humans; Macula Lutea - pathology; Male; Medical imaging; multidisciplinary; Retina; Retina - pathology; Retrospective Studies; Science; Science (multidisciplinary); Surgery; Tomography, Optical Coherence; Variance analysis; Vitrectomy
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-70197-6

The purpose of this cross-sectional retrospective study was to determine the relationship between the retinal displacements and the retinal thickness in eyes with epiretinal membrane (ERM) after vitrectomy with internal limiting membrane (ILM) peeling. To accomplish this, we measured the retinal thickness using optical coherence tomography (OCT) and the retinal displacement using OCT angiography to obtain 3 mm × 3 mm en face images before, and 2, 4, and 8 weeks following the surgery from 20 eyes of 20 patients. The distance between the retinal vessel bifurcations and the fovea was significantly displaced centrifugally and asymmetrically in the 4 quadrants postoperatively (
P
 < 0.001). The foveal avascular zone (FAZ) was significantly enlarged, and the central foveal thickness (CFT) and the inner nuclear layer (INL) thickness were significantly thinner postoperatively. The displacements were significantly correlated with the changes in the FAZ area (r = 0.717,
P
 < 0.001), the CFT (r = − 0.702,
P
 < 0.001), and the INL thickness (r = − 0.702,
P
 < 0.001). In conclusion, the distance between the retinal bifurcations and the fovea was asymmetrically expanded after the surgery and was significantly correlated with the morphological changes. These results indicate that a horizontal macular contraction is correlated with vertical retinal contraction in the eyes with an ERM.