Altered striatal response to reward in bulimia nervosa after recovery

• Published in: The International journal of eating disorders Vol. 43; no. 4; pp. 289 - 294
• Main Authors: Wagner, Angela, Aizenstein, Howard, Venkatraman, Vijay K, Bischoff-Grethe, Amanda, Fudge, Julie, May, J. Christopher, Frank, Guido K, Bailer, Ursula F, Fischer, Lorie, Putnam, Karen, Kaye, Walter H
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-05-2010; Wiley; Wiley Subscription Services, Inc
• Subjects: Adult; Adult and adolescent clinical studies; Anorexia; Basal Ganglia - physiopathology; binge eating disorder; binging; Biological and medical sciences; body image; Brain Mapping; Bulimia; bulimia nervosa; Bulimia Nervosa - physiopathology; Bulimia Nervosa - therapy; disease prevention; Eating behavior disorders; Eating disorders; Emotions; Emotions - physiology; Feedback, Psychological - physiology; Female; Humans; Hypotheses; Magnetic Resonance Imaging; Medical sciences; Motivation; NMR; Nuclear magnetic resonance; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; psychotherapy; recovery; Reference Values; Reward; striatum; Young Adult; bulimia nervosa; magnetic resonance imaging; Central nervous system; Basal ganglion; Corpus striatum; Eating disorder; Nuclear magnetic resonance imaging; Recovery; Encephalon; Bulimia; striatum; Medical imagery; Reward
• ISSN: 0276-3478; 1098-108X
• DOI: 10.1002/eat.20699

OBJECTIVE:: It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder. METHOD:: This hypothesis was tested by assessing functional magnetic resonance brain imaging response to a monetary reward task known to activate the anterior ventral striatum (AVS), a region implicated in motivational aspects toward stimuli. To avoid the confounding effects of malnutrition, 10 women who had recovered from bulimia nervosa (BN) were compared with 10 healthy comparison women (CW). RESULTS:: For the AVS, CW distinguished positive and negative feedback, whereas recovered BN women had similar responses to both conditions. In addition, these groups had similar patterns of findings for the dorsal caudate. DISCUSSION:: We have previously shown that individuals recovered from anorexia nervosa (AN) also had altered striatal responses and difficulties in differentiating positive and negative feedback. Thus BN and AN individuals may share a difficulty in discriminating the emotional significance of a stimulus. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010