Multicenter study on deep brain stimulation in Parkinson's disease: An independent assessment of reported adverse events at 4 years

• Published in: Movement disorders Vol. 23; no. 3; pp. 416 - 421
• Main Authors: Hariz, Marwan I., Rehncrona, Stig, Quinn, Niall P., Speelman, Johannes D., Wensing, Carin
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15-02-2008; Wiley
• Subjects: adverse event; Aged; Biological and medical sciences; Case-Control Studies; Clinical Medicine; Deep Brain Stimulation; Deep Brain Stimulation - adverse effects; Deep Brain Stimulation - methods; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; disease; Female; Gait Disorders, Neurologic; Gait Disorders, Neurologic - etiology; Globus Pallidus; Globus Pallidus - physiology; Globus Pallidus - radiation effects; Humans; Klinisk medicin; Longitudinal Studies; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Mental Disorders; Mental Disorders - etiology; Middle Aged; Neurologi; Neurologic Examination; Neurology; Parkinson Disease; Parkinson Disease - therapy; Parkinson's; Parkinson's disease; Subthalamic Nucleus; Subthalamic Nucleus - physiology; Subthalamic Nucleus - radiation effects; Nervous system diseases; Parkinson's disease; Deep brain stimulation; Multicenter study; Central nervous system; Parkinson disease; adverse event; Encephalon; Cerebral disorder; Central nervous system disease; Complication; Degenerative disease; Subthalamic nucleus; globus pallidus; Extrapyramidal syndrome
• ISSN: 0885-3185; 1531-8257; 1531-8257
• DOI: 10.1002/mds.21888

Ongoing adverse events (AEs) at 4‐years postsurgery in 69 patients with advanced Parkinson′s disease (PD) who received deep brain stimulation (DBS) of the subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 20), in the framework of a subset of eight centers of a multicenter study, were analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, disease duration, and clinical condition were virtually identical, as was the duration of follow‐up. There were 64 AEs reported in 53% of STN DBS patients and eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed severe and were reported to be present “both with and without stimulation.” The majority of the AEs affected patients' cognitive, psychiatric and behavioral status, as well as speech, gait, and balance, and most of these AEs occurred in STN DBS patients. When comparing patients who exhibited AEs with those who did not, it was found that in the STN DBS group, the patients with AEs had a longer disease duration, as well as more gait disorders and psychiatric disturbances at baseline. © 2007 Movement Disorder Society