The choreography of neuroinflammation in Huntington's disease

• Published in: Trends in immunology Vol. 36; no. 6; pp. 364 - 373
• Main Authors: Crotti, Andrea, Glass, Christopher K
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-06-2015; Elsevier Limited
• Subjects: Allergy and Immunology; Alzheimer's disease; Animals; astrocytes; Brain; Cell division; Cytokines; Cytokines - immunology; Cytokines - metabolism; Gene expression; Humans; Huntingtin Protein; Huntington Disease - genetics; Huntington Disease - immunology; Huntington's disease; Immune system; Inflammation - genetics; Inflammation - immunology; macrophages; microglia; Microglia - immunology; Microglia - metabolism; Models, Immunological; Morphology; Mutation; Mutation - genetics; Mutation - immunology; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - immunology; Neurodegeneration; neuroinflammation; Neurons; Neurons - immunology; Neurons - metabolism; Oxidative stress; Pathogenesis; Plasma; Proteins; macrophages; astrocytes; Huntington's disease; neuroinflammation; microglia
• ISSN: 1471-4906; 1471-4981
• DOI: 10.1016/j.it.2015.04.007

Highlights • The etiology and role of inflammation in neurodegenerative diseases is unclear. • In HD, mutant Huntingtin in microglia promotes proinflammatory gene expression. • Peripheral immune cells appear to have little involvement in CNS inflammation in HD. • Cell-autonomous microglia reactivity may impact HD inflammation and pathogenesis.