Loss of The Retinoblastoma Tumor-Suppressor Gene in Parathyroid Carcinoma

• Published in: The New England journal of medicine Vol. 330; no. 11; pp. 757 - 761
• Main Authors: Cryns, Vincent L, Thor, Ann, Xu, Hong-Ji, Hu, Shi-Xue, Wierman, Margaret E, Vickery, Austin L, Benedict, William F, Arnold, Andrew
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 17-03-1994
• Subjects: Adenoma; Adenoma - genetics; Adenoma - metabolism; Adult; Aged; Alleles; Benign; Biological and medical sciences; Cancer; Cancer therapies; Carcinoma; Carcinoma - genetics; Carcinoma - metabolism; Cyclin D1; deletion; Deoxyribonucleic acid; DNA; Endocrine system; Endocrinopathies; Female; Gene Deletion; Genes; Genes, Retinoblastoma; Hospitals; Humans; Hyperparathyroidism; Lungs; Lymphatic system; Male; Malignant tumors; man; Medical research; Medical sciences; Metastasis; Middle Aged; Neuroendocrine tumors; Parathyroid; Parathyroid Neoplasms - genetics; Parathyroid Neoplasms - metabolism; Parathyroids. Parafollicular cells. Cholecalciferol. Phosphocalcic homeostasis (diseases); Pathogenesis; Pathology; Patients; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Proteins; RB gene; Retina; Retinoblastoma; Retinoblastoma protein; Retinoblastoma Protein - metabolism; role; Surgery; Thyroid gland; tumor suppressor genes; Tumors; Endocrinopathy; Human; Carcinoma; Parathyroid diseases; Pathogenesis; Parathyroid glands; Malignant tumor; Inactivation; Retinoblastoma; Tumor suppressor gene
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199403173301105

Parathyroid carcinomas are malignant neoplasms that are an uncommon but often devastating cause of hyperparathyroidism
1
–
3
. These malignant tumors are usually associated with more profound clinical manifestations of hyperparathyroidism than are parathyroid adenomas, the benign, clonal tumors
4
that are the most frequent cause of primary hyperparathyroidism. Parathyroid carcinomas may recur locally or metastasize to regional lymph nodes, the lungs, the liver, the pancreas, or bone. Patients with metastatic disease generally die of complications of recurrent hypercalcemia
1
–
3
. The only curative treatment for parathyroid carcinoma is en bloc resection of the primary tumor
1
–
3
. Parathyroid carcinoma and adenoma . . .