Magnetic resonance elastography in staging liver fibrosis in non-alcoholic fatty liver disease: a pooled analysis of the diagnostic accuracy

• Published in: BMC gastroenterology Vol. 20; no. 1; p. 89
• Main Authors: Liang, Yuanzi, Li, Daowei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06-04-2020; BioMed Central; BMC
• Subjects: Accuracy; Bias; Bile; Biopsy; Cirrhosis; Development and progression; Diagnosis; Elasticity Imaging Techniques - methods; Fatty liver; Fibrosis; Gastroenterology; Humans; Liver cancer; Liver cirrhosis; Liver Cirrhosis - diagnostic imaging; Liver Cirrhosis - pathology; Liver diseases; Liver fibrosis; Magnetic resonance elastography; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Non-alcoholic fatty liver disease; Non-alcoholic Fatty Liver Disease - diagnostic imaging; Non-alcoholic Fatty Liver Disease - pathology; Patients; Quality; Quality control; Researchers; Sensitivity and Specificity; Severity of Illness Index; Software reviews; Studies; Systematic review; China; Systematic review; Magnetic resonance elastography; Liver fibrosis; Non-alcoholic fatty liver disease
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-020-01234-x

This study was performed to systematically evaluate the accuracy of magnetic resonance elastography (MRE) in staging of liver fibrosis in non-alcoholic fatty liver disease (NAFLD).
PUBMED, EMBASE, Web of Science, CNKI, Cochrane Library database were searched from January 2008 to December 2018 for studies related to MRE in the diagnosis of NAFLD liver fibrosis. The quality of the included literature was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. The pooled sensitivity, the pooled specificity, and area under the receiver operating characteristic curve (AUROC) value was performed by STATA 14.0 software.
A total of 12 studies were included, involving 910 patients. The pooled sensitivity and specificity of each group were 0.77 (95%CI 0.69-0.83) and 0.90 (95%CI 0.83-0.94) for F ≥ 1 (mild liver fibrosis), 0.87 (95%CI 0.74-0.94) and 0.86 (95%CI 0.71-0.94) for F ≥ 2 (significant liver fibrosis), 0.89 (95%CI 0.81-0.94) and 0.84 (95%CI 0.63-0.94) for F ≥ 3(severe liver fibrosis), 0.94 (95%CI 0.85-0.98) and 0.75 (95%CI 0.35-0.94) for F ≥ 4 (early cirrhosis), respectively. The area under the summary receiver operating characteristic (SROC) curve was 0.89, 0.93, 0.93, and 0.95, respectively.
MRE has high accuracy in the diagnosis of hepatic fibrosis staging in patients with NAFLD.