Recent advances of sonodynamic therapy in cancer treatment

• Published in: Cancer biology & medicine Vol. 13; no. 3; pp. 325 - 338
• Main Authors: Wan, Guo-Yun, Liu, Yang, Chen, Bo-Wei, Liu, Yuan-Yuan, Wang, Yin-Song, Zhang, Ning
• Format: Journal Article
• Language: English
• Published: China Research Center of Basic Medical Science & School of Pharmacy, Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics Theranostics, Tianjin Medical University, Tianjin 300070, China 01-09-2016; Chinese Anti-Cancer Association; China Anti-Cancer Association
• Subjects: cancer; reactive oxygen species; Review; Sonodynamic therapy; sonosensitizer; ultrasound; Reactive oxygen species; Ultrasound; Sonodynamic therapy; Sonosensitizer; Cancer; sonosensitizer; cancer; ultrasound; reactive oxygen species
• ISSN: 2095-3941; 2095-3941
• DOI: 10.20892/j.issn.2095-3941.2016.0068

Sonodynamic therapy （SDT） is an emerging approach that involves a combination of low-intensity ultrasound and specialized chemical agents known as sonosensitizers. Ultrasound can penetrate deeply into tissues and can be focused into a small region of a tumor to activate a sonosensitizer which offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. In this article, we critically reviewed the currently accepted mechanisms of sonodynamic action and summarized the classification of sonosensitizers. At the same time, the breath of evidence from SDT-based studies suggests that SDT is promising for cancer treatment.