The prognostic significance of the advanced lung cancer inflammation index in patients with unresectable metastatic colorectal cancer: a retrospective study

• Published in: BMC cancer Vol. 19; no. 1; p. 241
• Main Authors: Shibutani, Masatsune, Maeda, Kiyoshi, Nagahara, Hisashi, Fukuoka, Tatsunari, Matsutani, Shinji, Kimura, Kenjiro, Amano, Ryosuke, Hirakawa, Kosei, Ohira, Masaichi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 18-03-2019; BioMed Central; BMC
• Subjects: Albumin; Body mass index; Cancer metastasis; Cancer patients; Cancer research; Cancer therapies; Cell number; Chemotherapy; Clinical outcomes; Colorectal cancer; Colorectal carcinoma; Inflammation; Inflammatory marker; Lung cancer; Lymphocytes; Medical imaging; Medical prognosis; Metastases; Metastasis; Metastatic colorectal cancer; Musculoskeletal system; Neutrophils; Novels; Prognosis; Sarcopenia; Studies; Survival analysis; Japan; Inflammatory marker; Body mass index; Prognosis; Metastatic colorectal cancer
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-019-5468-9

Growing evidence indicates that inflammation contributes to cancer progression, and several inflammatory markers have been reported to be associated with the clinical outcomes in patients with various types of cancer. Recently, the advanced lung cancer inflammation index (ALI) has been developed as a prognostic marker in patients with lung cancer. The difference between the ALI and the inflammatory markers reported in the previous studies is that the ALI contains not only indices related to inflammation but also the body mass index (BMI), which was reported to correlate with the sarcopenic status. The aim of this study was to evaluate the prognostic significance of the ALI in patients with unresectable metastatic colorectal cancer.
We retrospectively reviewed a database of 159 patients who underwent combination chemotherapy for unresectable metastatic colorectal cancer between 2008 and 2016. The BMI was calculated by dividing the weight by height squared. The neutrophil-to-lymphocyte ratio (NLR) was calculated from a blood sample by dividing the absolute neutrophil count by the absolute lymphocyte count. The ALI was defined as follows: ALI=BMI × serum albumin concentration/NLR.
The overall survival rate was significantly worse in the low-ALI group than in the high-ALI group (p < 0.0001). Furthermore, the ALI was an independent prognostic factor for the overall survival (hazard ratio: 2.773, 95% confidence interval: 1.773-4.335, p < 0.001).
A newly developed prognostic marker, the ALI, was found to be a novel prognostic marker in patients with unresectable metastatic colorectal cancer as well as in patients with lung cancer.