PET-CT has low specificity for mediastinal staging of non-small-cell lung cancer in an endemic area for tuberculosis: a diagnostic test study (LACOG 0114)

• Published in: BMC cancer Vol. 19; no. 1; p. 5
• Main Authors: Werutsky, Gustavo, Hochhegger, Bruno, Lopes de Figueiredo Pinto, José Antônio, Martínez-Mesa, Jeovany, Zanini, Mara Lise, Berdichevski, Eduardo Herz, Vilas, Eduardo, da Silva, Vinícius Duval, Tsukazan, Maria Teresa Ruiz, Vieira, Arthur, Fritscher, Leandro Genehr, Hartmann, Louise, Alba, Marcos, Sartori, Guilherme, Matushita, Cristina, Bortolotto, Vanessa, do Amaral, Rayssa Ruszkowski, Junior, Luís Carlos Anflor, Zaffaroni, Facundo, Barrios, Carlos H, Debiasi, Márcio, Frietscher, Carlos Cezar
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03-01-2019; BioMed Central; BMC
• Subjects: Adult; Aged; Analysis; Biopsy; Cancer research; Cancer staging; Carcinoma, Non-Small-Cell Lung - complications; Carcinoma, Non-Small-Cell Lung - diagnosis; Carcinoma, Non-Small-Cell Lung - diagnostic imaging; Carcinoma, Non-Small-Cell Lung - pathology; CAT scans; Chronic granulomatous disease; Communicable diseases; Computed tomography; Diagnostic imaging; Diagnostic tests; Diagnostic Tests, Routine - methods; Disease; Endemic Diseases; Family medical history; Female; Granulomatous infectious diseases; HIV; HIV infections; Human immunodeficiency virus; Humans; Infectious diseases; Invasiveness; Lung cancer; Lymph node biopsy; Lymph nodes; Lymphatic system; Male; Mediastinal staging; Mediastinoscopy; Mediastinum - diagnostic imaging; Medical imaging; Medical research; Medical tests; Metastasis; Middle Aged; Neoplasm Staging - methods; Non-small cell lung cancer; Non-small cell lung carcinoma; Ostomy; Patients; PET-CT; Physicians; Positron emission tomography; Positron Emission Tomography Computed Tomography; Respiratory system agents; Small cell lung cancer; Small cell lung carcinoma; Sport utility vehicles; Surgeons; Surgery; Thoracic surgery; Tomography; Tomography, X-Ray Computed; Tuberculosis; Tuberculosis - complications; Tuberculosis - diagnosis; Tuberculosis - diagnostic imaging; Tuberculosis - pathology; Brazil; Mediastinal staging; PET-CT; Non-small cell lung cancer; Granulomatous infectious diseases
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-018-5233-5

The present study aims to assess the performance of 18F-FDG PET-CT on mediastinal staging of non-small cell lung cancer (NSCLC) in a location with endemic granulomatous infectious disease.
Diagnostic test study including patients aged 18 years or older with operable stage I-III NSCLC and indication for a mediastinal lymph node biopsy. All patients underwent a 18F-FDG PET-scan before invasive mediastinal staging, either through mediastinoscopy or thoracotomy, which was considered the gold-standard. Surgeons and pathologists were blinded for scan results. Primary endpoint was to evaluate sensitivity, specificity and positive and negative predictive values of PET-CT with images acquired in the 1st hour of the exam protocol, using predefined cutoffs of maximal SUV, on per-patient basis.
Overall, 85 patients with operable NSCLC underwent PET-CT scan followed by invasive mediastinal staging. Mean age was 65 years, 49 patients were male and 68 were white. One patient presented with active tuberculosis and none had HIV infection. Using any SUV_max > 0 as qualitative criteria for positivity, sensitivity and specificity were 0.87 and 0.45, respectively. Nevertheless, even when the highest SUV cut-off was used (SUV_max ≥5), specificity remained low (0.79), with an estimated positive predictive value of 54%.
Our findings are in line with the most recent publications and guidelines, which recommend that PET-CT must not be solely used as a tool to mediastinal staging, even in a region with high burden of tuberculosis.
The LACOG 0114 study was registered at ClinicalTrials.gov , before study initiation, under identifier NCT02664792.