Seasonal variations of vitamin D and its relation to lipid profile in Iranian children and adults

• Published in: Journal of health, population and nutrition Vol. 36; no. 1; p. 21
• Main Authors: Nouri Saeidlou, Sakineh, Vahabzadeh, Davoud, Babaei, Fariba, Vahabzadeh, Zakaria
• Format: Journal Article
• Language: English
• Published: Bangladesh BioMed Central Ltd 22-05-2017; BioMed Central; BMC
• Subjects: Adolescent; Adult; Adults; Age; Alfacalcidol; Analysis; Assaying; Biomarkers - blood; Blood; Blood pressure; Blood tests; Calcifediol; Calcifediol - blood; Child; Child, Preschool; Children; Cholesterol; Cholesterol - blood; Clinical trials; Correlation; Cross-Sectional Studies; Demographics; Demography; Diabetes; Disorders; Endocrinology; Enzyme-linked immunosorbent assay; Exposure; Fasting; Female; Functional anatomy; Gender; High density lipoprotein; High performance liquid chromatography; Humans; Hypercholesterolemia - blood; Hypercholesterolemia - epidemiology; Hypercholesterolemia - ethnology; Hypercholesterolemia - etiology; Insulin resistance; Iran; Iran - epidemiology; Lipid profile; Lipids; Liquid chromatography; Low density lipoprotein; Low density lipoproteins; Male; Middle Aged; Multivariate analysis; Nutrition; Nutrition Surveys; Pediatrics; Plasma; Population; Prevalence; Random sampling; Reproducibility of Results; Sampling; Seasonal variations; Seasonal variations (Diseases); Seasons; Serum; Serum levels; Severity of Illness Index; Sex Factors; Subgroups; Summer; Sunlight; Triglycerides; Vitamin D; Vitamin D Deficiency - blood; Vitamin D Deficiency - epidemiology; Vitamin D Deficiency - ethnology; Vitamin D Deficiency - physiopathology; Vitamin D3; Vitamin deficiency; Volunteers; Winter; Womens health; Young Adult; Iran; United States > US; Lipid profile; Adult; Iran; Vitamin D; Child
• ISSN: 2072-1315; 1606-0997; 2072-1315
• DOI: 10.1186/s41043-017-0096-y

Vitamin D has a multitude of functional properties and acts like a hormone in the body. Its effect on the lipid profile is one of the proposed mechanisms for its relationship with many disorders during its deficiency. But, this relationship is still conflicting and debatable, so this study was conducted to determine the association between serum level of vitamin D and lipid profiles, including serum concentrations of cholesterol, triglyceride (TG), HDL, and LDL in healthy subjects.
In this cross-sectional study, 541 volunteers with age of 5-60 years from normal and healthy subjects were selected via random sampling. Demographics and history of daily or weekly sunlight exposures were recorded. Measuring vitamin D was done in two consecutive seasons: winter and summer. Ten milliliters of peripheral venous blood sample was withdrawn after an overnight fasting. Serum levels of 25(OH) D (25, hydroxy vitamin D3) were measured using the enzyme-linked immunosorbent assay (ELISA), and the Confirmatory test was done by high-performance liquid chromatography (HPLC).
Mean age in the total mixed population was 30.83 ± 14.02 years. Subjects were 50.5% male and 49.5% female. Mean 25(OH) D in the total population for winter and summer were 45.8 ± 24.26 ng/ml and 55.24 ± 37.47 ng/ml respectively. In the total population, 38.08% were vitamin D deficient. Comparing serum lipid levels in the summer and winter showed a significant difference for cholesterol, LDL, and HDL, but no significant effect was found for TG. Analysis for the comparison of lipid profiles between the two genders in winter showed that there were significant differences in all lipid profiles except for LDL, while such analysis for summer revealed significant difference just for TG. In multivariate analysis, there was a significant mean difference only for LDL in subgroups with vitamin D insufficiency and deficiency. There was no correlation between Vitamin D and lipid profiles.
Vitamin D is different between the two seasons regardless of gender variations. Its status showed some significant relationship with some lipid profiles (cholesterol, LDL, and HDL) during the two seasons. There were different results among winter and summer based on the gender.