Comparative evaluation of the efficacy of two modes of delivery of diclofenac for the management of post-endodontic pain: A randomized controlled clinical trial

• Published in: Journal of pharmacy & bioallied science Vol. 15; no. 6; pp. 1283 - 1286
• Main Authors: Dheeraj, Munish, Johar, Suksham, Mahajan, Priya, Jandial, Tania, Chauhan, Shikha, Gupta, Kamakshi
• Format: Journal Article
• Language: English
• Published: Mumbai Wolters Kluwer India Pvt. Ltd 01-07-2023; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: Analgesics; Care and treatment; Clinical trials; Diclofenac; endodontic pain; Medical research; Medicine, Experimental; Nonsteroidal anti-inflammatory drugs; Original; Pain; Patients; transdermal drug; Transdermal medication; endodontic pain; transdermal drug; Diclofenac
• ISSN: 0975-7406; 0976-4879; 0975-7406
• DOI: 10.4103/jpbs.jpbs_119_23

Background: This study aimed to compare the efficacy of two modes of delivery of diclofenac for the management of post-endodontic pain. Materials and Methods: This study comprised 30 patients reporting to the department with pain in their teeth. Pain was assessed using the visual analog scale (VAS): group A (control group), group B (oral diclofenac), and group C (transdermal patch). A VAS was given to the patients in each group, and the severity of any pain was self-assessed by patients after 4 hrs, 8 hrs, 12 hrs, 24 hrs, and 48 hrs following the completion of treatment. Results: A comparison between group oral and diclofenac transdermal patch was carried out. The pain frequency was measured at 4 hrs, 8 hrs, 12 hrs, 24 hrs, and 48 hrs postoperatively with P values of 0.744, 0.035, 0.570, 0.060, and 0.508 and was statistically insignificant. Conclusion: Preoperative analgesics play an important role in reducing post-endodontic pain. Transdermal patches containing diclofenac show a promising analgesic modality in managing endodontic pain.