Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia

Inhibition of Erythroid Progenitor Cells by Anti-Kell Antibodies in Fetal Alloimmune Anemia

The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33). 1 , 2 The Kell antigen is expressed only by erythroid progenitor cells and mature ery...

Full description

Saved in:
Bibliographic Details
Published in:The New England journal of medicine Vol. 338; no. 12; pp. 798 - 803
Main Authors: Vaughan, Janet I, Manning, Monica, Warwick, Ruth M, Letsky, Elizabeth A, Murray, Neil A, Roberts, Irene A.G
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 19-03-1998
Subjects:
Anemia
Anemia, Hemolytic, Autoimmune
Anemias. Hemoglobinopathies
Antibodies, Monoclonal - physiology
Biological and medical sciences
Cell Division - immunology
Cells
Diseases of red blood cells
Erythroblastosis, Fetal - blood
Erythroblastosis, Fetal - etiology
Erythroblastosis, Fetal - immunology
Erythroid Precursor Cells - immunology
Erythroid Precursor Cells - physiology
Erythropoiesis - immunology
Female
Fetal Blood - immunology
Fetuses
Hematologic and hematopoietic diseases
Hematopoietic Stem Cells - physiology
Humans
Immunity (Disease)
Infant, Newborn
Isoantibodies - physiology
Kell Blood-Group System - immunology
Medical research
Medical sciences
Pregnancy
Rh-Hr Blood-Group System - immunology
Severity of Illness Index
Immunopathology
Evaluation
Erythroid cell
Congenital
Antibody
Dyserythropoietic anemia
Hemopathy
Serology
In vitro
Kell system
Genetic disease
Fetus
Blood cell count
Comparative study
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Kell blood-group system is one of the major antigenic systems in human red cells. It consists of 23 known antigens that reside on one 93-kd transmembrane protein encoded by a single gene on chromosome 7 (7q33). 1 , 2 The Kell antigen is expressed only by erythroid progenitor cells and mature erythroid cells. 1 , 3 , 4 The Kell blood group is important in clinical medicine because antibodies to the principal antigen, K1, cause both life-threatening transfusion reactions and severe alloimmune anemia in Kell-positive fetuses and newborn infants. 5 , 6 Alloimmunization occurs when Kell-negative women, who do not have the K1 antigen on their . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199803193381204