Influence of advanced life support response time on out-of-hospital cardiac arrest patient outcomes in Taipei

• Published in: PloS one Vol. 17; no. 4; p. e0266969
• Main Authors: Chen, Hsuan-An, Hsu, Shuo-Ting, Hsieh, Ming-Ju, Sim, Shyh-Shyong, Chu, Sheng-En, Yang, Wen-Shuo, Chien, Yu-Chun, Wang, Yao-Cheng, Lee, Bin-Chou, Huang, Edward Pei-Chuan, Lin, Hao-Yang, Ma, Matthew Huei-Ming, Chiang, Wen-Chu, Sun, Jen-Tang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14-04-2022; Public Library of Science (PLoS)
• Subjects: Adult; Airway management; Biology and Life Sciences; Cardiac arrest; Cardiopulmonary Resuscitation; Care and treatment; Clinical outcomes; Complications and side effects; CPR; Electric Countershock; Emergency medical care; Emergency Medical Services; Emergency response; Emergency services; Engineering and Technology; Fires; Heart; Hospitals; Humans; Intubation; Life support systems (Critical care); Medical care; Medical prognosis; Medical schools; Medicine; Medicine and Health Sciences; Mortality; Out-of-Hospital Cardiac Arrest; Patient outcomes; Patients; Physical Sciences; Quality management; Reaction Time; Registries; Response time; Resuscitation; Rhythm; Subgroups; Survival; Teams; Technicians; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0266969

The association between out-of-hospital cardiac arrest patient survival and advanced life support response time remained controversial. We aimed to test the hypothesis that for adult, non-traumatic, out-of-hospital cardiac arrest patients, a shorter advanced life support response time is associated with a better chance of survival. We analyzed Utstein-based registry data on adult, non-traumatic, out-of-hospital cardiac arrest patients in Taipei from 2011 to 2015.
Patients without complete data, witnessed by emergency medical technicians, or with response times of ≥ 15 minutes, were excluded. We used logistic regression with an exposure of advanced life support response time. Primary and secondary outcomes were survival to hospital discharge and favorable neurological outcomes (cerebral performance category ≤ 2), respectively. Subgroup analyses were based on presenting rhythms of out-of-hospital cardiac arrest, bystander cardiopulmonary resuscitation, and witness status.
A total of 4,278 cases were included in the final analysis. The median advanced life support response time was 9 minutes. For every minute delayed in advanced life support response time, the chance of survival to hospital discharge would reduce by 7% and chance of favorable neurological outcome by 9%. Subgroup analysis showed that a longer advanced life support response time was negatively associated with the chance of survival to hospital discharge among out-of-hospital cardiac arrest patients with shockable rhythm and pulse electrical activity groups.
In non-traumatic, adult, out-of-hospital cardiac arrest patients in Taipei, a longer advanced life support response time was associated with declining odds of survival to hospital discharge and favorable neurologic outcomes, especially in patients presenting with shockable rhythm and pulse electrical activity.