Parieto-frontal network in humans studied by cortico-cortical evoked potential

• Published in: Human brain mapping Vol. 33; no. 12; pp. 2856 - 2872
• Main Authors: Matsumoto, Riki, Nair, Dileep R., Ikeda, Akio, Fumuro, Tomoyuki, LaPresto, Eric, Mikuni, Nobuhiro, Bingaman, William, Miyamoto, Susumu, Fukuyama, Hidenao, Takahashi, Ryosuke, Najm, Imad, Shibasaki, Hiroshi, Lüders, Hans O.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-12-2012; Wiley-Liss; John Wiley & Sons, Inc
• Subjects: Adolescent; Adult; apraxia; Biological and medical sciences; cortico-cortical evoked potential; Electric Stimulation; Electrodiagnosis. Electric activity recording; Epilepsies, Partial - physiopathology; epilepsy; Evoked Potentials - physiology; Female; Frontal Lobe - physiology; Frontal Lobe - physiopathology; functional connectivity; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nerve Net - physiology; Nerve Net - physiopathology; Nervous system; Neural Pathways - physiology; Neural Pathways - physiopathology; Parietal Lobe - physiology; Parietal Lobe - physiopathology; parieto-frontal network; praxis movement; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Human; Nervous system diseases; Radiodiagnosis; Epilepsy; parieto-frontal network; Electrophysiology; Cerebral disorder; cortico-cortical evoked potential; functional connectivity; praxis movement; Evoked potential; Central nervous system disease; Frontal; Apraxia; Neurological disorder
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.21407

Parieto‐frontal network is essential for sensorimotor integration in various complex behaviors, and its disruption is associated with pathophysiology of apraxia and visuo‐spatial disorders. Despite advances in knowledge regarding specialized cortical areas for various sensorimotor transformations, little is known about the underlying cortico‐cortical connectivity in humans. We investigated inter‐areal connections of the lateral parieto‐frontal network in vivo by means of cortico‐cortical evoked potentials (CCEPs). Six patients with epilepsy and one with brain tumor were studied. With the use of subdural electrodes implanted for presurgical evaluation, network configuration was investigated by tracking the connections from the parietal stimulus site to the frontal site where the maximum CCEP was recorded. It was characterized by (i) a near‐to‐near and distant‐to‐distant, mirror symmetric configuration across the central sulcus, (ii) preserved dorso‐ventral organization (the inferior parietal lobule to the ventral premotor area and the superior parietal lobule to the dorsal premotor area), and (iii) projections to more than one frontal cortical sites in 56% of explored connections. These findings were also confirmed by the standardized parieto‐frontal CCEP connectivity map constructed in reference to the Jülich cytoarchitectonic atlas in the MNI standard space. The present CCEP study provided an anatomical blueprint underlying the lateral parieto‐frontal network and demonstrated a connectivity pattern similar to non‐human primates in the newly developed inferior parietal lobule in humans. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.