Palladium-Catalyzed Hydrocarboxylation of Alkynes with Formic Acid

Palladium-Catalyzed Hydrocarboxylation of Alkynes with Formic Acid

A palladium‐catalyzed hydrocarboxylation of alkynes with formic acid has been developed. The method provides acrylic acid and derivatives in good yields with high regioselectivity without the need to handle toxic CO gas. Nontoxic: Acrylic acids are an important chemical feedstock. The title reaction...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 54; no. 21; pp. 6302 - 6305
Main Authors: Hou, Jing, Xie, Jian-Hua, Zhou, Qi-Lin
Format: Journal Article
Language:English
Published: Weinheim WILEY-VCH Verlag 18-05-2015
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Edition:International ed. in English
Subjects:
Acrylic acid
Alkynes
Carbon monoxide
carboxylic acids
Derivatives
Feedstock
Formic acid
Handles
palladium
P ligands
synthetic methods
Toxic
Toxicology
palladium
P ligands
synthetic methods
alkynes
carboxylic acids
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A palladium‐catalyzed hydrocarboxylation of alkynes with formic acid has been developed. The method provides acrylic acid and derivatives in good yields with high regioselectivity without the need to handle toxic CO gas. Nontoxic: Acrylic acids are an important chemical feedstock. The title reaction provides acrylic acid and derivatives in good yields with high regioselectivities without the need to handle toxic CO gas.
Bibliography:ark:/67375/WNG-KRX3DF8F-Z
istex:D6E4CA3F79E4607A35A1022DBE91144BC088BA9E
National Natural Science Foundation of China
National Basic Research Program of China - No. 2012CB821600
Ministry of Education of China
We thank the National Natural Science Foundation of China, the National Basic Research Program of China (2012CB821600), and the "111" project (B06005) of the Ministry of Education of China for financial support.
ArticleID:ANIE201501054
We thank the National Natural Science Foundation of China, the National Basic Research Program of China (2012CB821600), and the “111” project (B06005) of the Ministry of Education of China for financial support.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201501054