Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine

• Published in: Physiology & behavior Vol. 119; pp. 92 - 96
• Main Authors: Osto, Melania, Abegg, Kathrin, Bueter, Marco, le Roux, Carel W, Cani, Patrice D, Lutz, Thomas A
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 02-07-2013; Elsevier
• Subjects: Animals; Bariatric surgery; Behavioral psychophysiology; Biological and medical sciences; dieting; energy balance; Fundamental and applied biological sciences. Psychology; Gastric Bypass - adverse effects; GLP-1; Gut microbiota; hormones; intestinal microorganisms; Intestine, Small - microbiology; Male; Microbiota; prebiotics; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; small intestine; weight loss; Gut microbiota; GLP-1; DPP 4; dipeptidyl peptidase-4; Bariatric surgery; Vertebrata; Mammalia; Rat; Digestive system; Animal; Rodentia; Gut; Surgical anastomosis; Microflora
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/j.physbeh.2013.06.008

Roux-en-Y gastric bypass (RYGB) surgery might modify the gut microbiota composition differently in the three distinct anatomical sections of the small intestine compared to sham surgery. We showed that RYGB induced changes in the microbiota of the alimentary limb and the common channel resembling those seen after prebiotic treatment or weight loss by dieting. These changes may be associated with altered production of intestinal hormones known to control energy balance. Postsurgical modulation of gut microbiota may significantly contribute to the beneficial metabolic effects of RYGB surgery.