Protein deacetylases and axonal regeneration

A neuron with injured or severed axon responds with attempts at axonal regrowth. In this regard, axonal regeneration of peripheral nerves occurs far more efficiently compared to central nervous system （CNS） neurons. The latter typically could not form a proper growth cone, and any axonal regeneratio...

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Bibliographic Details
Published in:	Neural regeneration research Vol. 10; no. 6; pp. 870 - 871
Main Authors:	Ng, Fanny, Tang, Bor Luen
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-06-2015 Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications
Subjects:	Gene expression Health aspects Histones Kinases Mammals Nerve regeneration Nervous system Neurological research Neurons Proteins Roles 中枢神经系统去乙酰化酶硫酸软骨素神经元神经发生细胞外基质蛋白轴突再生
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Summary:	A neuron with injured or severed axon responds with attempts at axonal regrowth. In this regard, axonal regeneration of peripheral nerves occurs far more efficiently compared to central nervous system （CNS） neurons. The latter typically could not form a proper growth cone, and any axonal regeneration in vivo is very limited. The adult CNS environment is not conducive for axonal regrowth. An extensive body of work has revealed mechanisms whereby the myelin-associated inhibitors and extracellular matrix chondroitin sulfate proteoglycans promote collapse of axonal growth cones or repel their advances （Lee and Zheng, 2012）. The intrinsic axonal regeneration capacity of an injured neuron is, however,
Bibliography:	A neuron with injured or severed axon responds with attempts at axonal regrowth. In this regard, axonal regeneration of peripheral nerves occurs far more efficiently compared to central nervous system （CNS） neurons. The latter typically could not form a proper growth cone, and any axonal regeneration in vivo is very limited. The adult CNS environment is not conducive for axonal regrowth. An extensive body of work has revealed mechanisms whereby the myelin-associated inhibitors and extracellular matrix chondroitin sulfate proteoglycans promote collapse of axonal growth cones or repel their advances （Lee and Zheng, 2012）. The intrinsic axonal regeneration capacity of an injured neuron is, however 11-5422/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1673-5374 1876-7958
DOI:	10.4103/1673-5374.158333