Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis

Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis

Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically between 20 and 40 years of age. A diagnosis of clinically definite multiple sclerosis requires the occurrence of at least two neurologic events...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 343; no. 13; pp. 898 - 904
Main Authors: Jacobs, Lawrence D, Beck, Roy W, Simon, Jack H, Kinkel, R. Phillip, Brownscheidle, Carol M, Murray, Thomas J, Simonian, Nancy A, Slasor, Peter J, Sandrock, Alfred W
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 28-09-2000
Subjects:
b-Interferon
b1a-Interferon
Biological and medical sciences
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Multiple sclerosis
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system
Neurology
Optic nerve
Patients
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Human
Nervous system diseases
Kaplan Meier estimator
Multiple sclerosis
Treatment efficiency
Cytokine
Central nervous system
Controlled therapeutic trial
Exploration
Nuclear magnetic resonance imaging
Intramuscular administration
Inflammatory disease
Randomization
Treatment
Demyelination
Central nervous system disease
Beta interferon
Double blind study
Medical imagery
Adult
Survival curve
Brain (vertebrata)
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Summary:Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically between 20 and 40 years of age. A diagnosis of clinically definite multiple sclerosis requires the occurrence of at least two neurologic events consistent with demyelination that are separated both anatomically in the central nervous system and temporally. 1 Magnetic resonance imaging (MRI) of the brain, by identifying lesions consistent with the occurrence of demyelination, can add certainty to the diagnosis. 2 , 3 The presence of such MRI-identified lesions in a patient with an isolated syndrome of the optic nerve . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200009283431301