Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis

Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically between 20 and 40 years of age. A diagnosis of clinically definite multiple sclerosis requires the occurrence of at least two neurologic events...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 343; no. 13; pp. 898 - 904
Main Authors:	Jacobs, Lawrence D, Beck, Roy W, Simon, Jack H, Kinkel, R. Phillip, Brownscheidle, Carol M, Murray, Thomas J, Simonian, Nancy A, Slasor, Peter J, Sandrock, Alfred W
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 28-09-2000
Subjects:	b-Interferon b1a-Interferon Biological and medical sciences Investigative techniques, diagnostic techniques (general aspects) Medical sciences Multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nervous system Neurology Optic nerve Patients Radiodiagnosis. Nmr imagery. Nmr spectrometry Human Nervous system diseases Kaplan Meier estimator Multiple sclerosis Treatment efficiency Cytokine Central nervous system Controlled therapeutic trial Exploration Nuclear magnetic resonance imaging Intramuscular administration Inflammatory disease Randomization Treatment Demyelination Central nervous system disease Beta interferon Double blind study Medical imagery Adult Survival curve Brain (vertebrata)
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Summary:	Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically between 20 and 40 years of age. A diagnosis of clinically definite multiple sclerosis requires the occurrence of at least two neurologic events consistent with demyelination that are separated both anatomically in the central nervous system and temporally. 1 Magnetic resonance imaging (MRI) of the brain, by identifying lesions consistent with the occurrence of demyelination, can add certainty to the diagnosis. 2 , 3 The presence of such MRI-identified lesions in a patient with an isolated syndrome of the optic nerve . . .
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM200009283431301