Advances in the study of berberine and its derivatives： a focus on anti-inflammatory and anti- tumor effects in the digestive system

It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications,...

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Bibliographic Details
Published in:	Acta pharmacologica Sinica Vol. 38; no. 2; pp. 157 - 167
Main Authors:	Zou, Kun, Li, Zhao, Zhang, Yong, Zhang, Hao-yue, Li, Bo, Zhu, Wei-liang, Shi, Ji-ye, Jia, Qi, Li, Yi-ming
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-02-2017 Nature Publishing Group
Subjects:	Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Berberine - analogs & derivatives Berberine - pharmacology Berberine - therapeutic use Biomedical and Life Sciences Biomedicine Digestive System - drug effects Humans Immunology Internal Medicine Medical Microbiology Pharmacology/Toxicology Review Structure-Activity Relationship Vaccine 天然产物小檗碱慢性炎症抗炎活性抗肿瘤作用治疗效果消化系统衍生物 digestive system anticancer drug anti-inflammatory drug structure-activity relationship natural product berberine
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Summary:	It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic with a long history. Over the past decade, many reports have demonstrated that this natural product and its derivatives have high activity against both cancer and inflammation In this review, we sqmmarize the advances in studing berberine and its derivatives as anti-inflammatory and anti-tumor agents in the digestive system; we also discuss their structure-activity relationship. These data should be useful for the development of this natural product as novel anticancer drugs with anti-inflammation activity.
Bibliography:	berberine; natural product; anti-inflammatory drug; anticancer drug; digestive system; structure-activity relationship It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic with a long history. Over the past decade, many reports have demonstrated that this natural product and its derivatives have high activity against both cancer and inflammation In this review, we sqmmarize the advances in studing berberine and its derivatives as anti-inflammatory and anti-tumor agents in the digestive system; we also discuss their structure-activity relationship. These data should be useful for the development of this natural product as novel anticancer drugs with anti-inflammation activity. 31-1347/R ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1671-4083 1745-7254
DOI:	10.1038/aps.2016.125