Lipoprotein(a) as a predictor of poor collateral circulation in patients with chronic stable coronary heart disease

• Published in: Brazilian journal of medical and biological research Vol. 50; no. 8; p. e5979
• Main Authors: Fan, Y, Hu, J-S, Guo, F, Lu, Z-B, Xia, H
• Format: Journal Article
• Language: English
• Published: Brazil Associacao Brasileira de Divulgacao Cientifica (ABDC) 01-01-2017; Associação Brasileira de Divulgação Científica
• Subjects: Analysis; Angiography; BIOLOGY; Biomarkers - blood; Cardiac patients; Cohort Studies; Collateral Circulation - physiology; Coronary Angiography; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - physiopathology; Coronary Circulation - physiology; Coronary collateral circulation; Coronary heart disease; Coronary Occlusion - blood; Coronary Occlusion - diagnostic imaging; Coronary Occlusion - physiopathology; Diagnosis; Female; Health aspects; Humans; Lipoprotein A; Lipoprotein(a) - blood; Male; Medical research; MEDICINE, RESEARCH & EXPERIMENTAL; Middle Aged; Predictive Value of Tests; Predictor; Risk Factors; Coronary collateral circulation; Predictor; Lipoprotein(a)
• ISSN: 0100-879X; 1414-431X; 1414-431X
• DOI: 10.1590/1414-431X20175979

As a mechanism compensating for obstructive coronary artery disease, coronary collateral circulation (CCC) has attracted cardiologists for a long time to explore its potential impact. In the present study, Chinese patients suffering from ≥95% coronary stenosis, as diagnosed by angiography, have been investigated for the correlation between CCC and lipoprotein(a) [Lp(a)] levels. A cohort of 654 patients was divided into four categories according to Rentrop grades 0, 1, 2, and 3. Lp(a) levels were divided into model 1, discretized with critical values of 33 and 66%, and model 2, discretized with a cutoff value of 30.0 mg/dL. Furthermore, we evaluated the correlation between CCC and serum Lp(a) levels. The four groups had significantly different Lp(a) levels (25.80±24.72, 18.99±17.83, 15.39±15.80, and 8.40±7.75 mg/dL; P<0.001). In model 1, concerning R0, the risk in the third Lp (a) tertile (OR=3.34, 95%CI=2.32-4.83) was greater than that in the first tertile. In model 2, concerning R0, the risk in Lp(a) >30.0 group (OR=6.77, 95%CI=4.44-10.4) was greater than that of Lp(a) <30.0 mg/dL. The worst condition of CCC can be predicted independently by Lp(a) levels. In addition to clinical usage, Lp(a) levels can also be utilized as biological markers.