Amniotic membrane extract and eye drops: a review of literature and clinical application

• Published in: Clinical ophthalmology (Auckland, N.Z.) Vol. 12; pp. 1105 - 1112
• Main Authors: Murri, Michael S, Moshirfar, Majid, Birdsong, Orry C, Ronquillo, Yasmyne C, Ding, Yanning, Hoopes, Phillip C
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: AME; AMEED; amnion; Amniotic membrane; Amniotic membrane extract; Amniotic membrane extract eye drop; amniotic membrane transplant; AMT; Anti-inflammatory agents; Apoptosis; Burns; Care and treatment; Chemical burns; Collagen; corneal wound healing; Cytokines; Epidermal growth factor; Eye diseases; Fibroblasts; Genesis; Medicine; Ophthalmic agents; Ophthalmology; Proteins; Regener-eyes; Regenesol; Review; Stem cells; Studies; Technology application; Transplants & implants; Tumor necrosis factor-TNF; umbilical cord; Wound care; Wound healing; United States > US; AMEED; AMT; Regener-Eyes; amniotic membrane extract; corneal wound healing; Regenesol; amniotic membrane; amniotic membrane transplant; AME; Genesis; umbilical cord; amnion; amniotic membrane extract eye drops
• ISSN: 1177-5467; 1177-5483; 1177-5483
• DOI: 10.2147/OPTH.S165553

The amniotic membrane (AM) has a long history of use in the treatment of various diseases of the ocular surface. It contains pluripotent cells, highly organized collagen, anti-fibrotic and anti-inflammatory cytokines, immune-modulators, growth factors, and matrix proteins. It is used to promote corneal healing in severely damaged eyes. Recently, AM extract and AM extract eye drops have been successfully used in clinical applications, including dry eye and chemical burns. We provide an overview on the recent progress in the preparation, mechanisms of action, and use of AM extract/AM extract eye drops for corneal and external eye diseases.