Future dentistry: cell therapy meets tooth and periodontal repair and regeneration

• Published in: Journal of cellular and molecular medicine Vol. 15; no. 5; pp. 1054 - 1065
• Main Authors: Catón, Javier, Bostanci, Nagihan, Remboutsika, Eumorphia, De Bari, Cosimo, Mitsiadis, Thimios A.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01-05-2011; John Wiley & Sons, Inc
• Subjects: Animals; Bioengineering; Biology; Cell growth; Cell therapy; Cell- and Tissue-Based Therapy - methods; Connective tissue; Dental enamel; Dental pulp; Dentistry; Extracellular matrix; Growth factors; Humans; implants; Medicin och hälsovetenskap; Molecular modelling; odontoblast; Periodontal Diseases - pathology; Periodontal Diseases - therapy; Periodontal ligament; Periodontium; Progenitor cells; Prostheses; Regeneration; Repair & maintenance; Reviews; Stem cells; Teeth; Tissue engineering; Tissue Engineering - methods; tooth; Tooth - physiology; Transcription factors; Transplants & implants
• ISSN: 1582-1838; 1582-4934; 1582-4934
• DOI: 10.1111/j.1582-4934.2010.01251.x

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Introduction
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The need for tooth tissue engineering
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Cellular components and development of tooth
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Bases for tooth tissue engineering
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The patient as a recipient and as the source of cells
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Dental stem cell based tissue engineering
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Dental pulp stem cells (DPSCs)
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The clinical application of DPSCs in regeneration of the pulp/dentin complex
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Periodontal tissues as a source and niche for stem cells
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Past, current and future approaches in periodontal regeneration
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Molecular mechanisms and factors regulating regeneration of periodontal tissues
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Scaffolding and material science
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Conclusions
Cell‐based tissue repair of the tooth and – tooth‐supporting – periodontal ligament (PDL) is a new attractive approach that complements traditional restorative or surgical techniques for replacement of injured or pathologically damaged tissues. In such therapeutic approaches, stem cells and/or progenitor cells are manipulated in vitro and administered to patients as living and dynamic biological agents. In this review, we discuss the clonogenic potential of human dental and periodontal tissues such as the dental pulp and the PDL and their potential for tooth and periodontal repair and/or regeneration. We propose novel therapeutic approaches using stem cells or progenitor cells, which are targeted to regenerate the lost dental or periodontal tissue.