Changes over time in patient‐reported outcomes in patients with heart failure

• Published in: ESC Heart Failure Vol. 11; no. 2; pp. 811 - 818
• Main Authors: Jaarsma, Tiny, Kato, Naoko P., Klompstra, Leonie, Ben Gal, Tuvia, Boyne, Josiane, Hägglund, Eva, Vellone, Ercole, Hagenow, Andreas, Evangelista, Lorraine S., Mårtensson, Jan, Strömberg, Anna
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-04-2024; John Wiley and Sons Inc; Wiley
• Subjects: Body mass index; Chronic illnesses; Chronic obstructive pulmonary disease; Clinical outcomes; Cognitive ability; Creatinine; Exercise; Heart failure; Hemoglobin; Intervention; Marital status; Mental depression; Original; Patient-reported outcomes; Patients; Physical fitness; Quality of life; Questionnaires; Sleep; Symptoms; Italy; Sweden; Netherlands; Israel; United States > US; Germany; Heart failure; Patient-reported outcomes; Symptoms; Quality of life
• ISSN: 2055-5822; 2055-5822
• DOI: 10.1002/ehf2.14648

Aim
This paper describes the trajectory during 1 year of four patient‐reported outcomes (PROs), namely, sleep, depressive symptoms, health‐related quality of life (HrQoL), and well‐being, in patients with heart failure (HF), their relationship and the patient characteristics associated with changes in these PROs.
Methods and results
Data analyses of PROs from 603 patients (mean age 67 years; 29% female, 60% NYHA II) enrolled in the HF‐Wii study. On short term, between baseline and 3 months, 16% of the patients experienced continuing poor sleep, 11% had sustained depressive symptoms, 13% had consistent poor HrQoL, and 13% consistent poor well‐being. Across the entire 1‐year period only 21% of the patients had good PRO scores at all timepoints (baseline, 3, 6, and 12 months). All others had at least one low score in any of the PROs at some timepoint during the study. Over the 12 months, 17% had consistently poor sleep, 17% had sustained symptoms of depression, 15% consistently rated a poor HrQoL, and 13% poor well‐being. Different patient characteristics per PRO were associated with a poor outcomes across the 12 months. Age, education, New York Heart Association, and length of disease were related to two PRO domains and submaximal exercise capacity (6 min test), co‐morbidity, and poor physical activity to one.
Conclusion
In total, 79% of the patients with HF encountered problems related to sleep, depressive symptoms, HrQoL, and well‐being at least once during a 1‐year period. This underscores the need for continuous monitoring and follow‐up of patients with HF and the need for dynamic adjustments in treatment and care regularly throughout the HF trajectory.