Recovery and Sequence Analysis of Hepatitis A Virus from Springwater Implicated in an Outbreak of Acute Viral Hepatitis

• Published in: Applied and Environmental Microbiology Vol. 74; no. 19; pp. 6158 - 6160
• Main Authors: Tallon, Lindsay A, Love, David C, Moore, Zack S, Sobsey, Mark D
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-10-2008; American Society for Microbiology (ASM)
• Subjects: Biological and medical sciences; Colony Count, Microbial; Disease control; Disease Outbreaks; Disease prevention; Drinking water; Enterobacteriaceae - isolation & purification; Epidemics; Feces; Fresh Water - virology; Fundamental and applied biological sciences. Psychology; Genetics; Genomics; Genotype; Hepatitis; Hepatitis A - epidemiology; Hepatitis A - virology; Hepatitis A virus; Hepatitis A virus - classification; Hepatitis A virus - genetics; Hepatitis A virus - isolation & purification; Humans; Microbiology; Molecular Epidemiology; Molecular Sequence Data; North Carolina - epidemiology; Phylogeny; Public health; Public Health Microbiology; RNA, Viral - genetics; Sequence Analysis; Sequence Homology; Viruses; North Carolina; Infection; Virus; Epidemic; Viral hepatitis; Hepatitis A virus; Picornaviridae; Viral disease; Hepatovirus
• ISSN: 0099-2240; 1098-5336; 1098-6596
• DOI: 10.1128/AEM.02872-07

An outbreak of acute hepatitis A virus in North Carolina was linked to drinking water from a contaminated shallow spring by phylogenetic analysis of hepatitis A virus (HAV) genomic sequences. Detection of HAV and fecal indicators in the water provided useful and timely information to assist with public health prevention and control measures.