Synchronous Triple Lung Cancers after Treatment for Non-Hodgkin's Lymphoma: Metachronous Quadruple Cancers

• Published in: Internal Medicine Vol. 42; no. 10; pp. 1031 - 1034
• Main Authors: TOKUCHI, Yoshio, KAMACHI, Masafumi, HARADA, Masao, HASEGAWA, Masaru, MlSHINA, Takayuki, YAMASHIRO, Katsushige, SUZUKI, Hiroaki, ISOBE, Hiroshi
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 2003; Japanese Society of Internal Medicine
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Biological and medical sciences; Carcinoma, Large Cell - etiology; Carcinoma, Squamous Cell - etiology; chemotherapy; Cyclophosphamide - adverse effects; Doxorubicin - adverse effects; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; lung cancer; Lung Neoplasms - etiology; Lymphoma, Non-Hodgkin - drug therapy; Lymphoma, Non-Hodgkin - radiotherapy; Male; malignant lymphoma; Medical sciences; multiple cancer; Neoplasms, Multiple Primary - etiology; Neoplasms, Second Primary - etiology; Prednisone - adverse effects; Radiotherapy - adverse effects; secondary cancer; Vincristine - adverse effects; Antineoplastic agent; Lung disease; Multiple; multiple cancer; Respiratory disease; Malignant hemopathy; Malignant tumor; Non Hodgkin lymphoma; Bronchopulmonary malignant tumor; lung cancer; Synchronous; Chemotherapy; Treatment; Second cancer; Lymphoproliferative syndrome; secondary cancer; Bronchus disease; Malignant lymphoma
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.42.1031

After chemotherapy and radiotherapy for non-Hodgkin's lymphoma during a one-year period, a 66-year-old man developed synchronous triple lung cancers in both lungs. Of the three resected tumors, one was advanced large cell carcinoma with neuroendocrine morphology, and the other two were early squamous cell carcinoma without lymph node metastasis. Although he received repeated chemotherapy for lung cancer, the patient died of hepatic failure due to multiple liver metastases. Autopsy revealed disseminated metastasis of the large cell carcinoma with neuroendocrine morphology throughout the entire body, but no recurrence of malignant lymphoma or squamous cell carcinoma was found. To our knowledge, this is the first report of triple lung cancers occurring after treatment for malignant lymphoma. (Internal Medicine 42: 1031-1034, 2003)