Selectins and Platelet-Derived Growth Factor (PDGF) in Schistosomiasis-Associated Pulmonary Hypertension

• Published in: Lung Vol. 192; no. 6; pp. 981 - 986
• Main Authors: Lapa, Monica, Acencio, Milena M. P., Farias, Alberto Q., Teixeira, Lisete R., Fernandes, Caio J. C., Jardim, Carlos P., Terra-Filho, Mario
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-12-2014; Springer; Springer Nature B.V
• Subjects: Adult; Analysis of Variance; Biomarkers - metabolism; Care and treatment; Case-Control Studies; Complications and side effects; Development and progression; Endothelium, Vascular - metabolism; Endothelium, Vascular - physiopathology; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Forced Expiratory Volume; Genetic aspects; Humans; Hypertension, Pulmonary - blood; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - diagnosis; Male; Medicine; Medicine & Public Health; Middle Aged; Pathology; Patient outcomes; Physiological aspects; Physiology; Platelet-derived growth factor; Platelet-Derived Growth Factor - metabolism; Pneumology/Respiratory System; Pulmonary hypertension; Reference Values; Risk Assessment; Risk factors; Schistosomiasis; Schistosomiasis - blood; Schistosomiasis - complications; Schistosomiasis - diagnosis; Selectins - metabolism; Severity of Illness Index; Tropical diseases; Vasculitis - metabolism; Vasculitis - physiopathology; Brazil; Selectins; Endothelial dysfunction; Schistosomiasis; Pulmonary hypertension
• ISSN: 0341-2040; 1432-1750
• DOI: 10.1007/s00408-014-9643-0

Purpose
The aim of this study was to evaluate the expression profiles of the relevant selectins and PDGF in schistosomiasis-associated pulmonary hypertension.
Methodology
Patients with three distinct clinical profiles were enrolled in the study: IPAH(
n
 = 11), schistosomiasis-associated PH (Sch-PH))(
n
 = 13), and schistosomiasis without PH (Sch) (
n
 = 13). Healthy volunteers, were recruited as a control group(
n
 = 13). Echocardiography was performed in all groups, and the PH patients underwent right heart catheterization. Plasma soluble adhesion molecules E- and P-Selectin, PDGF-AB, PDGF-BB were determined by ELISA.
Results
E-selectin was significantly increased in the IPAH group compared with the other groups [the control, Sch + PH and Sch groups) (
p
 < 0.001) (Fig. 
2
)]. P-selectin was lower in Sch (20.2 + 8.9 × 103 pg/mL) as compared to the control, (43 16.8 × 103 pg/mL), IPAH (35.8 7.8 × 103 pg/mL), and Sch + PH (36.8 ± 15.7 × 103 pg/mL) (
p
 = 0.005) groups. Serum PDGF-BB levels were higher in the control group (8.9 ± 4.8 × 103 pg/mL) compared with the IPAH (3.7 ± 2.17 × 103 pg/mL), Sch + PH (5.2 ± 3.7 × 103 pg/mL) and Sch (2.4 ± 1.7 × 103 pg/mL) groups (
p
 < 0.05). PDGF-AB levels were also higher in the control group (25.6 ± 8.6 × 103 pg/mL), compared with the other three groups, being the Sch group the one with lower serum levels of this marker (11.4 ± 8.6 × 103 pg/mL) (
p
 = 0.006).
Conclusions
In conclusion, vascular inflammation in schistosomiasis, with or without PH, is different from IPAH suggesting distinct pathophysiological mechanisms associated with the development of pulmonary hypertension.