The Salmonella -containing vacuole—Moving with the times

• Published in: Current opinion in microbiology Vol. 11; no. 1; pp. 38 - 45
• Main Author: Steele-Mortimer, Olivia
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01-02-2008; Current Biology
• Subjects: Actins - metabolism; Bacterial Proteins - metabolism; Bacteriology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Intracellular Membranes - metabolism; Membrane Transport Proteins - metabolism; Microbiology; Microtubules - metabolism; Miscellaneous; Pathology; Protein Transport; Salmonella; Salmonella enterica - physiology; Vacuoles - microbiology; Virulence Factors - metabolism; Salmonella; Bacteria; Vacuole; Enterobacteriaceae
• ISSN: 1369-5274; 1879-0364
• DOI: 10.1016/j.mib.2008.01.002

Salmonella pathogenesis is dependent on its ability to invade and replicate within host cells. Following invasion the bacteria remain within a modified phagosome known as the Salmonella -containing vacuole (SCV), within which they will survive and replicate. Invasion and SCV biogenesis are dependent on two Type III secretion systems, T3SS1 and T3SS2, which are used to translocate distinct cohorts of bacterial effector proteins into the host cell. Elucidating the roles of individual effector proteins in SCV biogenesis has proven difficult but several distinct themes are now emerging and it is apparent that SCV biogenesis is an extremely dynamic process involving; extensive membrane remodeling, interactions with the endolysosomal pathway, actin rearrangements and microtubule-based movement and tubule extension.