Smoking cessation behaviors three months following acute insular damage from stroke

• Published in: Addictive behaviors Vol. 51; pp. 24 - 30
• Main Authors: Abdolahi, Amir, Williams, Geoffrey C, Benesch, Curtis G, Wang, Henry Z, Spitzer, Eric M, Scott, Bryan E, Block, Robert C, van Wijngaarden, Edwin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-12-2015; Elsevier Science Ltd
• Subjects: Acute Disease; Brain Ischemia - etiology; Brain Ischemia - physiopathology; Cerebral Cortex - physiopathology; Cessation; Cohort Studies; Drug use; Female; Follow-Up Studies; Health Behavior; Humans; Insular cortex; Intervention; Male; Middle Aged; Nicotine; Prospective Studies; Psychiatry; Recurrence; Smoking; Smoking cessation; Smoking Cessation - statistics & numerical data; Stroke; Stroke - complications; Stroke - physiopathology; Tobacco Use Disorder - therapy; United States > US; Rochester New York; Stroke; Cessation; Insular cortex; Nicotine; Smoking
• ISSN: 0306-4603; 1873-6327
• DOI: 10.1016/j.addbeh.2015.07.001

Abstract Background Recent evidence suggests that the insular cortex may play an important role in cognitive and emotional processes that facilitate drug use but it is unclear whether changes to the insula would result in sustained abstinence. To better understand the role of the insula in maintaining abstinence, we examined quitting patterns in smokers with acute damage to their insula relative to other regions. Design Prospective cohort study with 3 month follow-up, beginning June 2013 and ending May 2014. Setting Three acute care hospitals in Rochester, NY. Participants One-hundred-fifty-six current smokers hospitalized for acute ischemic stroke; 38 with insular infarctions and 118 with non-insular infarctions, assessed by 3 neuroradiologists. Measurements Self-reported smoking status (seven-day point prevalence and continuous abstinence), complete abstinence from any nicotine product, and disruption of smoking addiction (defined by criteria on smoking status, difficulty of quitting, and urge) were assessed at three months post-stroke. Time to relapse (in days) after discharge was also assessed. Results Insular damage was associated with increased odds of three-month continuous abstinence (OR = 3.71, 95% CI: 1.59, 8.65) and complete cessation from any nicotine product (OR = 2.72, 95% CI: 1.19, 6.22). Average time to relapse was longer in the insular-damaged group (17.50 days, SD = 19.82) relative to non-insular damage (10.42 days, SD = 18.49). Among quitters, insular damage was also associated with higher relative odds of experiencing a disruption of addiction compared to non-insular damage (adjusted OR = 5.60, 95% CI: 1.52, 20.56). Conclusions These findings support the potential role of the insular cortex in maintaining smoking and nicotine abstinence. Further research is needed to establish whether the insula may be a novel target for smoking cessation interventions.