Diabetic Neuropathy: Current Status and Future Prospects

Diabetic peripheral neuropathy (DPN) and diabetic autonomic neuropathy (DAN) are the most common diabetes-related microvascular complications and can result in significant increase in morbidity, such as chronic pain, foot ulcerations and amputations, and mortality. There exists an urgent need to ide...

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Bibliographic Details
Published in:	Journal of diabetes research Vol. 2017; pp. 5825971 - 2
Main Authors:	Tavakoli, Mitra, Gogas Yavuz, Dilek, Tahrani, Abd A., Selvarajah, Dinesh, Bowling, Frank L., Fadavi, Hassan
Format:	Journal Article
Language:	English
Published:	England Hindawi 01-01-2017 Hindawi Limited
Subjects:	Amputation Biomarkers Clinical trials Diabetes Diabetic Neuropathies - drug therapy Diabetic Neuropathies - epidemiology Diabetic neuropathy Epidemiology Humans Hypoglycemic Agents - therapeutic use Lipids Neutrophils Pathogenesis Prevalence Spinal cord
Online Access:	Get full text
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Summary:	Diabetic peripheral neuropathy (DPN) and diabetic autonomic neuropathy (DAN) are the most common diabetes-related microvascular complications and can result in significant increase in morbidity, such as chronic pain, foot ulcerations and amputations, and mortality. There exists an urgent need to identify the most accurate early biomarker of nerve damage to better diagnose DPN in the clinical care of patients and, in particular, to permit an accurate evaluation of future therapies in clinical trials. V. L. Newton et al. demonstrated the increased numbers of neutrophils and levels of L-selectin which is an adhesion molecule important for neutrophil transmigration, in the lumbar spinal cord after 8 weeks of STZ-induced diabetic rats.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Commentary-2 content type line 23 ObjectType-Editorial-3
ISSN:	2314-6745 2314-6753
DOI:	10.1155/2017/5825971